About My Health Careers Internship MedBlogs Contact us

Microparticles Embedded With Drugs Reduce Scarring in Rats' Hearts

by Rajashri on October 20, 2008 at 3:50 PM
Font : A-A+

 Microparticles Embedded With Drugs Reduce Scarring in Rats' Hearts

Tiny polymer beads that can slowly release anti-inflammatory drugs, and break down into non-toxic components have been developed by an Indian-origin researcher.

Dr. Niren Murthy's beads have been tested by researchers at Emory University and Georgia Institute of Technology on rats, with some promising results.


The researchers injected them into rats' hearts after a simulated heart attack, and found that the drug-embedded "microparticles" reduce inflammation and scarring.

According to them, injecting the particles could cut the area of scar tissue formed after the heart attack in half, and boost the ability of the heart to pump blood by 10 percent weeks later.

"If you look at previous studies to see what it would take to get enough of these drugs into the heart, they did things like direct injections twice a day. And there are clear toxicity issues if the whole body is exposed to the drug," Nature Materials quoted Dr. Michael Davis, assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, as saying.

The researcher has revealed that the team turned to Murthy's microscopic particles, made of a material called polyketals, as an alternative.

He says that the microparticles break down over a few weeks in the body, releasing the experimental drug SB239063, which inhibits an enzyme called MAP kinase, which is important during the damaging inflammation that occurs after a heart attack.

Davis adds that the drug gradually leaches out of the polyketal particles - half is gone after a week of just sitting around in warm water.

The microparticles are also broken down by white blood cells called macrophages, the researcher says.

"These are actually cells we're trying to reach with the drug, because they're involved in the inflammatory response in the heart. The macrophages can surround and eat the particles, or fuse together if the particles are too big," he says.

Davis points out that polyketals have an advantage over other biodegradable polymers, in that they break down into neutral, excretable compounds that are not themselves inflammatory.

He highlights the fact that the main effect of using the particles was that it prevented the heart from the scarring, which sets in after the initial tissue damage of a heart attack.

He and Murthy are exploring polyketal particles as delivery vehicles for drugs or proteins in several organs: heart, liver, lungs and spinal cord.

Source: ANI

News A-Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity Heart Healthy Heart Drugs Banned in India 

Recommended Reading
Heart Attack
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the ......
Chest Pain
Ask any one who has experienced intense chest pain and they will vouch for the fact that it was the ...
Angioplasty - Animation
Arteries supplying the heart is sometimes blocked by plaque leading to heart attack.Angioplasty is ....
Heart Attack - Animation
Animation of Heart Attack symptoms. Heart attack is caused due to ischemia of the heart muscles ......
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use