About Careers Internship MedBlog Contact us

Microorganisms In The Womb Set Stage For Health Problems Later In Life

by Shirley Johanna on December 30, 2015 at 3:10 PM
Font : A-A+

Microorganisms In The Womb Set Stage For Health Problems Later In Life

A team of researchers reviewed the importance of microorganisms that exist in the gut. Perturbation of this environment during pregnancy, delivery and early infancy could impact the developing baby's microbiome and set stage for health problems later in life.

The term "microbiome" refers to the trillions of organisms we harbor, on our skin and within our respiratory and gastrointestinal tracts. "The Microbiome and Childhood Diseases," a special issue of the Birth Defects Research Part C EmbryoToday scientific journal, is a collection of ground breaking microbiota reviews.


One particularly noteworthy finding pertains to the womb environment in which the baby develops. "One of the reviews, by Koleva et al., discusses the studies that reveal that the womb is not sterile and that the microbiota of the child are already developing in utero," explained Sharon Meropol, MD, PhD, Associate Director for Research and Evaluation at University Hospitals Rainbow Babies & Children's Hospital's Center for Child Health and Policy.

"This means that not only do we have to consider the microbiome of the child but also that of the mother, and the irony is that some of our modern medical practices, through their effect on these early microbiota, could have unintended consequences, interfering with normal development of children's immune, metabolic, and neurologic systems."

The special issue is particularly timely as Birth Defects Prevention Month prepares to kick off in January. According to Dr. Meropol, increasing evidence supports the importance of protecting key steps in the transfer and maintenance of the normal microbiota in pregnant mothers and fetuses. "Disturbed microbiota could potentially contribute to a wide range of childhood diseases including allergies, asthma, obesity, and autism-like neurodevelopmental conditions," said Dr. Meropol, who is also Assistant Professor of Pediatrics at Case Western Reserve University School of Medicine. "But recent studies suggest that traditional practices like vaginal births, skin-to-skin contact immediately after birth and breastfeeding may promote the development of the microbiome in the infant and help set the trajectory towards healthy development."

UH Rainbow's visionary physician researchers John Kennell, MD, and Lydia Furman, MD, were early proponents of vaginal delivery, and kangaroo care (skin to skin contact) and breastfeeding immediately following birth, advising more than a decade ago that these practices are associated with psychosocial, metabolic and immunologic benefits for full-term and premature infants. [Furman L, Kennell, J. Acta Paediatr. 2000;89:1280] Since then, compelling evidence has continued to mount that these practices are beneficial for intergenerational transfer of the microbiome from mother to infant.

Dr. Meropol and Amy Edwards, MD, pediatric infectious disease specialist at UH Rainbow, provide an overview of the potential influences of the developing infant microbiome from the clinical perspective in the special issue of Birth Defects Research Part C EmbryoToday. "We have just scratched the surface in understanding how the internal universe of maternal, fetal and infant colonizing microbiota, interacting with genetic and environmental factors, can influence optimal child development," says Dr. Meropol. "We are grateful to The Teratology Society for recognizing the importance of this research and shedding light on the evolving story of the microbiome."

Source: Eurekalert

News A-Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Health Insurance - India 

Most Popular on Medindia

Sanatogen Blood - Sugar Chart Indian Medical Journals Iron Intake Calculator Drug - Food Interactions Find a Doctor Selfie Addiction Calculator Sinopril (2mg) (Lacidipine) Diaphragmatic Hernia Drug Side Effects Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

Microorganisms In The Womb Set Stage For Health Problems Later In Life Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests