There are many kinds of stressors that increase our risk for disease. But the ones that threaten our social standing, such as targeted rejection, seem to be particularly harmful.
This is the conclusion of a new study by researcher Michael Murphy of the University of British Columbia and colleagues
They examine the human immune response as a potential link between social stressors like rejection and later mental and physical health outcomes.
"Targeted rejection is central to some of life's most distressing experiences - things like getting broken up with, getting fired, and being excluded from your peer group at school. In this study, we aimed to examine processes that may give these experiences the ability to affect health," said Murphy.
Previous research has shown that people who are on the receiving end of this kind of rejection experience symptoms of depression three times faster than people who are faced with similarly severe life events.
Researchers believe that certain inflammatory processes that are part of the immune response could be a link between targeted rejection and depression.
Murphy and colleagues decided to directly investigate whether rejection-related life events affect inflammatory activity by conducting a study that followed 147 healthy adolescent women over 2.5 years.
The participants did not have a personal history of mental health problems but were all at risk for major depression due to family and other personal risk factors.
The participants were assessed for psychiatric diagnoses, incidences of targeted rejection, perceived social status, expression of inflammatory signalling molecules, and indicators of low-grade inflammation every 6 months over the course of the study.
The data collected suggest that recent exposure to targeted rejection does indeed activate the molecular signalling pathways that regulate inflammation. Participants had elevated levels of pro-inflammatory signalling molecules at visits when they had recently experienced an incidence of targeted rejection compared to visits when no targeted rejection had occurred.
Interestingly, the effect was more pronounced in those who perceived their social status to be higher.
Murphy and colleagues speculate that this inflammatory response might be adaptive for individuals at the top of a social hierarchy, giving them a survival advantage. The researchers noted, however, that an overly productive immune response could be harmful to mental and physical health in the long run.
If substantiated in future research, these findings could have implications for understanding how social conditions increase risk for a variety of inflammation-related diseases, including obesity, diabetes, cardiovascular disease, certain types of cancer, and depression.
The study was published in Clinical Psychological Science, a journal of the Association for Psychological Science.