About My Health Careers Internship MedBlogs Contact us

Mental and Physical Exercise Helps Improve Schizophrenia

by VR Sreeraman on August 4, 2007 at 2:54 PM
Font : A-A+

Mental and Physical Exercise Helps Improve Schizophrenia

Mental and physical exercise can help improve behavioural deficits in schizophrenia and repair damaged chemical transmitter pathways in the brain, a new study by researchers in Australia has shown.

The study, carried it out on a mouse model, was conducted by researchers at Melbourne's Howard Florey Institute in collaboration with a team from Mental Health Research Institute of Victoria.


As a part of their study researchers led by Dr Anthony Hannan, Dr Caitlin McOmish, and Emma Burrows characterised a genetically altered mouse and discovered that it had schizophrenia-like behaviours, including learning and memory problems, the inability to process complex information, and abnormal responses to particular sensory stimuli.

The scientists gave the mice enhanced mental and physical exercise - putting running wheels in their cages, plus interesting items to smell, see and touch, and found that their condition improved significantly.

They also noted that not only did the rodents' schizophrenia-like symptoms ease through physical and mental exercise, but that a specific chemical transmitter pathway found to be abnormal in the cerebral cortex of the mice was selectively rescued.

The researchers also tested an anti-psychotic drug used by humans on the mice and found that it improved their condition. This showed the team that this mouse model was a valid model for schizophrenia in humans.

Dr Hannan said this discovery could pave the way for the development of better treatments for schizophrenia.

"Through our research, and that of others, we hope a new class of therapeutic drugs will be developed that mimic the effects of environmental enrichment in the brain to treat various brain disorders, possibly including schizophrenia," Dr Hannan said.

"Pharmaceutical approaches may not be the sole answer for a given brain disease. People may still need optimal levels of physical and mental activity, as well as a healthy diet, plus the right drugs.

"We have already identified specific molecules that could be targets for what I call 'enviromimetics' and these may have relevance for other brain diseases. However, there are obviously major differences between mice and men, and large-scale clinical trials are needed to identify the most beneficial drugs," he said.

Schizophrenia is a brain disorder that is brought on through a complex and largely unknown interaction of genes and environment.

There is a nature-nurture aspect to schizophrenia because in human identical twins, if one twin develops schizophrenia, there is only a 50 percent chance the other twin, who has identical genes, will develop the illness.

This research is currently an advanced online publication of the international journal Molecular Psychiatry.

Source: ANI

News A-Z
News Category
What's New on Medindia
Memory Loss - Can it be Recovered?
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Schizophrenia Diet Lifestyle and Heart Disease Tips to Live Longer Exercise and Fitness Lifestyle Modification: No Big Deal! Body Types and Befitting Workouts Exercise To Gain Weight Top Health Tips to Overcome Tiredness Fitness Through Density Training Program Exercise 

Recommended Reading
Schizophrenia is a mental disorder characterized by symptoms of thought, behavior and social ......
Left-handers More at Risk of Developing Schizophrenia
People who are left-handed are at an increased risk of developing schizophrenia, a new study has ......
Body Types and Befitting Workouts
Workout and diet which is well suited for a pear shaped body....
It is important for us to understand the power of daily exercise. Only then can we motivate ourselve...
Exercise and Fitness
Exercise is about revamping your lifestyle, not just weight loss. Exercise to get healthy – that way...
Exercise To Gain Weight
Are you underweight and want to know how to gain weight? Exercise or workouts can help you gain weig...
Fitness through Density Training Program
Density Training is an effective weight training workout which helps to quickly build muscle and los...
Lifestyle Modification: No Big Deal!
Simple and practically possible lifestyle changes can make a huge difference in improving our health...
Tips to Live Longer
Though life is temporary and short, it is possible to maximize the span of our existence by living h...
Top Health Tips to Overcome Tiredness
If you follow a healthy lifestyle and still feel tired, you should rule out all possible medical cau...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use