About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Mechanisms That Support the Spread of Ovarian Cancer

by Bidita Debnath on October 11, 2016 at 11:52 PM
Font : A-A+

 Mechanisms That Support the Spread of Ovarian Cancer

Ovarian cancer is associated with a very high mortality rate, in part due to difficulties in detecting and diagnosing the disease at early stages before tumors have spread, or metastasized, to other locations in the body.

During metastasis, ovarian tumor cells break away from the original tumor site into the abdominal cavity, where immune cells called macrophages help them survive and migrate to other locations.

Advertisement


In this issue of the JCI, research led by Wang Min at Yale University describes how a subtype of macrophages communicate with and support tumor cell growth to drive metastasis in ovarian cancer. Researchers determined that tumor cells attract macrophages by releasing cytokines.

These macrophages then secrete growth factors that help the tumor cells multiply to form tumor cell spheroids. In a mouse model of ovarian cancer, inhibiting these growth factors reduced the formation of tumor cell spheroids and ovarian tumor growth.

These findings add to an understanding of the early stages of ovarian tumor metastasis, which may lead to the development of more effective early diagnostic approaches as well as therapies to prevent metastasis.

Source: Eurekalert
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Mechanisms That Support the Spread of Ovarian Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests