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Mechanism Behind Brain's Contribution to Insulin Resistance Found

by Rajashri on July 12, 2008 at 3:45 PM
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 Mechanism Behind Brain's Contribution to Insulin Resistance Found

The mechanism behind brain's contribution to the development of insulin resistance in body has been revealed by a new study from Albert Einstein College of Medicine, New York.

Insulin resistance refers to the inability of cells in the body to respond appropriately to the hormone insulin.

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Among the cells in the body that normally respond to insulin are nerves in a region of the brain known as the hypothalamus.

In the new study conducted over rats, Hiraku Ono and colleagues found that when rodents were fed a high-fat diet for a short period of time, the ability of insulin to prevent liver cells releasing stored glucose was reduced.
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This in turn reduced insulin-induced signalling and increased activation of a protein known as SK6 in the hypothalamus, which suppressed the ability of insulin to prevent glucose release

These data lead the authors to speculate that the earliest stages of diet-induced insulin resistance might be prevented by inhibition of S6K in the hypothalamus.

Source: ANI
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