An Indian-origin scientist at the Salk Institute for Biological Studies has announced the identification of the molecular mechanisms that underpin allergic reactions.
The molecular mechanisms that underpin allergic reactions have been identified by an Indian-origin scientist at the Salk Institute for Biological Studies.
Dr. Inder Verma, a professor in the Laboratory of Genetics, believes that this work may pave the way for new therapies to stop the summer sneezing, and to treat more severe allergic responses.
Allergy - Causes - Symptoms - Diagnosis - Treatment - FAQs - Videos
An allergy is a hypersensitive disorder of immune system. Substances that often cause allergic reactions are pollen, dust mites, mold spores, pet dander, food, insect stings and medicines.
An allergy is a hypersensitive disorder of immune system. Substances that often cause allergic reactions are pollen, dust mites, mold spores, pet dander, food, insect stings and medicines.
He says in a research article in the journal Cell that specialised cells in the body, mast cells, release the chemical histamine whenever an individual encounters an allergen, such as pollen, and thereby offer protection against the allergen.
However, he adds, this process can abnormally occur throughout the body in people with allergic diseases, leading to severe inflammation and in the worst cases, anaphylactic shock and death.
Atopic Dermatitis / Eczema - Causes - Symptoms - Diagnosis - Treatment - FAQs
Atopic dermatitis is an inflammatory, non-contagious, chronic skin disorder that involves scaly and itchy rashes. It is also called eczema, dermatitis or atopy.
Atopic dermatitis is an inflammatory, non-contagious, chronic skin disorder that involves scaly and itchy rashes. It is also called eczema, dermatitis or atopy.
While experimenting with mice, he says, it was observed that the animals with mast cells lacking IKK2 had reduced allergic reactions.
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Postdoctoral researcher Dr. Kotaro Suzuki, who led the current study, added: "IKK2 knock out mast cells couldn't release enough histamine."
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Children If Given Antibiotics in the First Three Months are Vulnerable to Asthma
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The research team is now testing inhibitors of IKK2 as acute treatment for allergic reactions.
They believe that IKK2 inhibitors may have the added benefit of reducing both the early and late phase allergic responses.
The researchers also think that IKK2 may have a role in pathologies like diabetes and nervous system diseases too.
Source-ANI
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