About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Measuring Cystatin C in the Blood Improves Estimation of Kidney Function

by Kathy Jones on September 6, 2013 at 9:11 PM
Font : A-A+

 Measuring Cystatin C in the Blood Improves Estimation of Kidney Function

Use of blood levels of cystatin C to estimate kidney function strengthens the association between kidney function and risks of death and end-stage renal disease, a new, international study from the Chronic Kidney Disease Prognosis Consortium has found.

The findings, reported in the September 5 edition of the New England Journal of Medicine, suggest that the use of cystatin C as a measurement of kidney function could lead to better staging and risk classification of chronic kidney disease. They also suggest that the measurement potentially could allow for more targeted management of the condition, allow for better and safer prescribing of medications, and more judicious use of procedures that may harm the kidney.

Advertisement

Kidney function estimates are central to the diagnosis and management of chronic kidney disease, and these estimates are usually based on the creatinine blood test. However, the creatinine test can miss early losses of kidney function, particularly in patients with low muscle mass.

Cystatin C, a newer kidney function marker, is becoming more widely available and in some settings provides improved estimates of kidney function.
Advertisement

For the study, the researchers performed a meta-analysis of 11 general-population studies (with 90,750 participants from the United States, Europe and Australia) and five studies of participants with chronic kidney disease (2,960 participants) for whom standardized measurements of serum creatinine and cystatin C were available. They compared the association of kidney function, as calculated by the measurement of creatinine, cystatin C, or the combination of creatinine and cystatin C, with the rates of death, death from cardiovascular causes, and end-stage kidney disease, and they compared kidney disease stages that were classified alternatively by creatinine or cystatin C.

Results of the analyses using cystatin C demonstrated that the risks associated with declining kidney function emerge when kidney function reaches approximately 85 ml per minute per 1.73 m2, much earlier than the threshold of chronic kidney disease (i.e., 60 ml/min/1.73m2). In contrast, with creatinine based kidney function estimates, these risks of kidney function cannot be observed until kidney function is below 60 ml/min/1.73m2 by which time chronic kidney disease has already developed. The kidney function stages categorized by cystatin C were much better at reflecting future risk than were the stages based upon creatinine estimates of kidney function.

"Clearly cystatin C defines an important preclinical period of reduced kidney function before chronic kidney disease can be diagnosed with creatinine alone, and this period may last one to two decades," said Michael Shlipak, MD, MPH, lead author of the article and chief of general internal medicine at the San Francisco VA Medical Center. Shlipak also is a professor of medicine, epidemiology and biostatistics at UCSF. "Cystatin C allows patients' kidney function to be categorized more accurately; the use of cystatin C in clinical medicine could help us to be more precise in the diagnosis of chronic kidney disease, and in the future to target high-risk patients for treatment in order to prevent chronic kidney disease."

Chronic kidney disease affects over 10 percent of adults worldwide. The researchers note that, unlike creatinine, cystatin C is not affected by muscle mass, so it requires less adjustment for factors like age and gender. In addition, cystatin C works similarly as a marker of kidney function in blacks and whites.

"Accurate detection and staging of chronic kidney disease are integral components of clinical medicine, since such evaluations have a major effect on disease labeling, interventions, drug doses, and risk stratification for clinical procedures," said Josef Coresh, MD, PhD, the Consortium's principal investigator and professor in the Johns Hopkins Bloomberg School's Department of Epidemiology. "Our study provides definitive evidence that the measurement of cystatin C improves risk categorization based on estimated kidney function, as judged by the risk of death from any cause and to a lesser extent the risks of death from cardiovascular causes and end-stage kidney disease."

"Cystatin C versus Creatinine in Determining Risk Based on Kidney Function" was written by the CKD Prognosis Consortium, which includes approximately 200 collaborators and data from 40 countries.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis Top Foods to Beat Chronic Fatigue Syndrome 

Recommended Reading
Dialysis
Dialysis is an artificial process for removing excess water and waste from the blood. Hemodialysis ....
Cysts and Tumours
Ultrasound scan reveals multiple cysts and there is no function on that kidney when tested on DMSA ....
Diabetic Kidney Disease
Diabetic nephropathy refers to kidney damage due very high levels of blood sugar levels in ......
Kidney Failure due to Melamine Toxicity
Adulteration of food with melamine results in the formation of kidney stones and kidney failure, ......
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Renal Tubular Acidosis
Renal tubular acidosis/RTA results in acid content of the blood being higher than normal and that of...
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain ca...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Top Foods to Beat Chronic Fatigue Syndrome
Suffering from chronic fatigue syndrome? Find out what foods can help you deal with the symptoms of ...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use