About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Maternal Immunity Not All Good for a Fetus

by VR Sreeraman on August 6, 2009 at 8:01 AM
Font : A-A+

 Maternal Immunity Not All Good for a Fetus

As a fetus does not mount an immune response to maternal proteins that cross the placenta, it has been assumed that a fetus would not reject non-genetically matched blood cells (specifically allogeneic blood cells) if they were transplanted while the fetus was in utero.

The hope is that this procedure, which is known as IUHCT, could provide a viable approach for treating congenital blood disorders. However, studies using a mouse model of IUHCT indicate that most fetal recipients of allogeneic blood cells lose their transplanted cells 3-5 weeks after transplantation.

Advertisement

Alan Flake and colleagues, at Children's Hospital of Philadelphia, have now identified an immune mechanism responsible for graft failure in this model of IUHCT. Surprisingly, although fetal immune cells eliminated the transplanted allogeneic blood cells, they were triggered to do so by immune molecules known as alloantibodies that they obtained from their mother's breast milk.

The maternal alloantibodies were produced in response to IUHCT and so the authors conclude that in the absence of either a maternal immune response or transmission of the maternal alloantibodies to the fetus, transplanted blood cells should not be rejected, leaving open the door for IUHCT as a potential clinical strategy.

Source: Eurekalert
SRM
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Immunisation Pregnancy and Antenatal Care Myasthenia Gravis Blood Group Diet Boils - Treatment by Drugs 

Recommended Reading
Expecting Mums With Disease Threat Have Offspring With Enhanced Immunity
Researchers at The University of Nottingham have found that expecting mothers produce less ......
Electronic Fetal Monitoring - Animation
Fetal monitoring records the condition of the fetus and contractions of the uterus during the ......
Mom’s Antibody Production Against Fetus’ Brain Linked to Child’s Autism
A new study shows that it may be the mother's production of antibodies against her baby's brain ......
Blood Group Diet
What is right diet for you may be the wrong one for another. The diet that suits you will depend on ...
Boils - Treatment by Drugs
Diabetes patients have reduced immunity, which makes them more susceptible to skin infections like b...
Myasthenia Gravis
Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gra...
Pregnancy and Antenatal Care
What is Antenatal care and its importance during pregnancy for mother and baby, with details on the ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use