Marine Animals Lack Valuable Gene to Fight Against Popular Pesticide

by Iswarya on  August 14, 2018 at 9:59 AM Environmental Health
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Marine animals such as dolphins, manatees, seals, and whales, which emerged to make water as their primary habitat lost the capability to produce a gene that protects humans and other land-dwelling animals from the neurotoxic effects of a human-made pesticide, reports a new study. The findings of the study are published in the journal Science.
Marine Animals Lack Valuable Gene to Fight Against Popular Pesticide
Marine Animals Lack Valuable Gene to Fight Against Popular Pesticide

The researchers found that the marine mammals lost the gene Paraoxonase 1 (PON1) that effectively defends humans and other terrestrial mammals from organophosphates a group of human-made insecticides.

PON1 potentially reduces cellular damage caused by unstable oxygen atoms and also protects us from organophosphates that kills by disrupting neurological systems.

Whales and dolphins lost the gene PON1 soon after they split from their common ancestor with hippopotamuses 53 million years ago; manatees lost it after their split from their common ancestor with elephants 64 million years ago.

But some seals likely lost PON1 function more recently, at most 21 million years ago and possibly in very recent times.

"The big question is, why did they lose function at PON1 in the first place? It's hard to tell whether it was no longer necessary or whether it was preventing them from adapting to a marine environment," said lead author Wynn K. Meyer, a postdoctoral associate at the University of Pittsburgh in the US.

"We know that ancient marine environments didn't have organophosphate pesticides, so we think the loss might instead be related to PON1's role in responding to the extreme oxidative stress generated by long periods of diving and rapid resurfacing," Meyer added.

The team analyzed DNA sequences from five species of marine mammals and 53 species of terrestrial mammals and reacted their blood samples with an organophosphate by-product.

The blood did not break down the organophosphate by-product the way it did in land mammals, indicating that unless a different biological mechanism is protecting the marine mammals, they would be susceptible to organophosphate poisoning a form of poisoning that results from the build-up of chemical signals in the body, especially the brain.

The study calls for monitoring our waterways to learn more about the impact of pesticides and agricultural run-off on marine mammals.

Source: IANS

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