The three-year study was published by British Heart Foundation as part of its Fight For Every Heartbeat campaign and revealed that there were 132 deaths due to heart disease for 10,000 people in Tameside, Greater Manchester, which meant that residents of the area were three times more likely to be diagnosed with coronary heart disease compared to those living in London.
Northern Ireland's Ballymoney came second with 129 deaths per 10,000 people while Glasgow was third with 128 deaths.
Says BHF medical director Professor Peter Weissberg, "These latest figures expose staggering inequalities in death from heart disease across the UK. But it's unacceptable that people continue to die from heart attacks, regardless of the postcode. Coronary heart disease is not beaten yet- it remains the single biggest killer in the UK. We urgently need people to unite behind our quest to fund research to eradicate this deadly disease wherever it strikes."