Medindia LOGIN REGISTER
Medindia
Advertisement

Man-Made Blood Vessel Shows Encouraging Results in Dialysis Graft

by Kathy Jones on November 23, 2013 at 8:54 PM
 Man-Made Blood Vessel Shows Encouraging Results in Dialysis Graft

A new study conducted by a Duke Medicine researcher reveals that an investigational, man-made blood vessel that is used in vascular grafts for kidney dialysis patients has shown encouraging results.

Presented at the American Heart Association Scientific Sessions meeting in Dallas, the early findings of this interim patient data track 28 hemodialysis patients who received grafts using the investigational bioengineered vessel during a multi-center study launched in Poland last December.

Advertisement

The investigational bioengineered blood vessel, designed to be the first off-the-shelf product incorporating human tissue in the bioengineering process, provided blood flow in 100 percent of the study patients, reported Jeffrey H. Lawson, M.D., Ph.D., professor of surgery and pathology at Duke University School of Medicine. Eight patients later lost blood flow, but it was restored with interventions in each case.

Lawson said there is a significant need for alternative types of vascular technology. Current synthetic vascular grafts used for hemodialysis access provide initial blood flood in less than 50 percent of patients at six months, and with secondary interventions the success rates rises to 77 percent, Lawson said.
Advertisement

Preliminary interim analysis of the investigational bioengineered vessel currently being used for dialysis among the Polish patients has resulted in no infections to date, no immune reactions and no sign of structural degeneration.

"These early data are very encouraging," said Lawson, who performed the first U.S. implantation of the blood vessel in June in a patient with end-stage kidney disease. "Longer term evaluations in a larger patient population are needed to confirm the early findings, but we are hopeful the technology continues to demonstrate potential benefit to dialysis patients."

The investigational bioengineered blood vessel is manufactured by Humacyte, Inc., a Duke University spin-off company from the lab of Laura Niklason, M.D., Ph.D., who is now vice chair of anesthesia and a professor of biomedical engineering at Yale University. Lawson has collaborated with Niklason and Humacyte for over 15 years to develop the bioengineered vessels.

The technology uses donated human tissue that grows on a biodegradable tubular scaffold, which gradually dissolves as the cells grow. The resulting vessel is then rinsed of its cellular properties, creating a collagen structure that does not appear in preliminary studies to trigger an immune response when implanted in humans. That feature, if established in future studies, could enable it to be mass-produced without tailoring it to individual patients.

The investigational bioengineered vessel is being tested initially as a vascular graft for patients with end-stage kidney disease who need dialysis procedures. An estimated 380,000 people in the United States receive dialysis, and costs associated with vein access complications are significant.

Subject to review and approval from regulatory agencies, subsequent tests of the technology are planned for replacement or bypass of diseased and injured blood vessels.



Source: Eurekalert
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Research News

NASH Cases Expected to Hit 26.55 Million in 7MM by 2032
Within the seven major markets, 12% to 20% of diagnosed prevalent NASH cases present severe liver damage (stage 4 liver fibrosis), denoting cirrhosis.
Can Sleep Brain Waves Defend Against Epileptic Activity?
Memory deficits in individuals with epilepsy, especially cognitive difficulties, might partially stem from the transient impairments caused by these slow waves.
High Altitude Training's Impact on Surgical Readiness
High altitude training exhibits potential benefits for pre-surgery patients, enhancing readiness, stated a new study.
AI Shows Promise in Identifying ADHD
The AI method shows promise in identifying imaging biomarkers for diagnosing ADHD.
Life Expectancy Gap for Autistic Individuals Revealed
Diagnosed autistic individuals showed increased premature mortality in the UK, highlighting urgent needs to address associated inequalities.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Man-Made Blood Vessel Shows Encouraging Results in Dialysis Graft Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests