Mesenchymal stem cells (MSCs) are inherently able to migrate toward tumors.
They also can differentiate under control into mesodermal cell types of
bone, fat, cartilage, muscle or connective tissue in vivo and in vitro.
Therefore, MSCs are very attractive for researchers and practical
physicians to apply them in substitute therapy, gene or cell
Scientists from the Tomsk Polytechnic University's Laboratory of
Novel Dosage are developing a technology to control mesenchymal stem
cells of patients. The technology will allow treating cancer more
effective. To fight cancer cells the scientists suggest using the
patient's own magnet controlled cells. Native body cells won't be
rejected by its immune system and can deliver medication directly into
the center of the disease.
‘A technology to control mesenchymal stem cells of patients has been developed by researchers. This will allow treating cancer more effectively.’
The development of magnetic cells is jointly carried out by Tomsk
Polytechnic University (TPU) and colleagues from Pavlov State Medical
University of St. Petersburg and Queen Mary University of London.
The novel technology implies that mesenchymal stem cells (MSCs) of
the patient's body with the size of about 10 microns are
internationalized with magnetic controlled microcapsules with drug
inside. External trigging (magnet) targets cells to tumor; make
microcontainers open and release encapsulated compound. Thus, drug is
precisely delivered affecting cancer cells and without causing harm to
For the first time, the scientists have demonstrated the efficiency
of internationalization of magnetic microcapsules by MSCs to
functionalize cells and to design magnetic controlled cells and tissue
"It is interesting to note MSCs exhibit a high capability to
internationalize (capture) microcapsules without significant toxicity
compared to other cell lines described in the literature. As a result of
magnetic capsules internalization by MSCs we create a new cell
engineering platform which is responsive to external magnetic field to
control cell migration. This way magnetization of MSCs enables magnetic
sorting of cells and form a cell spheroid out of tens of thousands of
MSCs. Also, the obtained results can be further used to create a next
generation cell-modified platform for efficient targeted delivery ex
vivo," the authors note.
The scientists have published their results in Advanced Healthcare Materials