Magic mouthwash can effectively treat pain related to mouth sores caused by radiation therapy for cancers of the head and neck, reports a new study.
'Magic mouthwash,' an oral rinse containing diphenhydramine, lidocaine, and antacids, significantly reduced pain from oral mucositis, mouth sores, in patients receiving radiation therapy for cancers of the head and neck when compared to placebo. These were the findings of a multi-institution, randomized, double-blind, placebo-controlled, phase III clinical trial, led by Robert Miller, M.D., an emeritus Mayo Clinic radiation oncologist. Dr. Miller and his colleagues published their findings in the JAMA.
"Our group published a study in 2012 showing that an oral rinse of doxepin reduced oral mucositis-related pain, compared to placebo," says Dr. Miller. "However, there were no large randomized controlled trials studying the potential benefits of magic mouthwash."
"Radiation therapy may cause mouth sores because it is designed to kill rapidly growing cells, such as cancer cells," says co-author, Terence Sio, M.D., a Mayo Clinic radiation oncologist in Arizona.
"Unfortunately, healthy cells in your mouth also divide and grow rapidly, and may be damaged during radiation therapy, which can cause discomfort. We're glad to have identified a proven method to help treat the discomfort of this side effect."