Madge, whose Sticky and Sweet world tour is commencing soon, has sacked two of her dancers in a fit. What's more, her bad moods also have her tour manager threatening to walk out.
Along with rehearsals for her show not going well, her health has also started to deteriorate and doctors have discovered that Madge is anaemic, a definite sign that she is overdoing it.
The 'Like a Virgin' singer also suffered a painful knee injury and so she now has a doctor, physiotherapist and a chiropractor on duty during rehearsals for her forthcoming Sticky and Sweet world tour.
After having been told to take it easy she is now taking time out and resting in New York State's Hamptons resort with close pal Gwyneth Paltrow.
The cause of her meltdown has been attributed to the crisis in her marriage to Guy Ritchie and allegations of a relationship between her and baseball star Alex 'A-Rod' Rodriguez.
The other blow came from her brother Christopher Ciccone, who penned a book about her. The strain has pushed her famous mood swings to terrifying new extremes.
"Madonna is doing less than OK. She has been rehearsing for the tour and she is totally miserable," the Sun quoted a source in her camp as saying.
"She's down physically and mentally. The situation with Guy is very, very tense. The way the press are going crazy with the A-Rod story, her brother's book and her physical exhaustion are all taking their toll.
"Family tension with her father and two of her other siblings has also been awkward.
"She feels nobody has taken her side. One of her closest pals says she has never seen Madonna so low. She has been feeling low and looking really gaunt.
"Madonna was told to go soft on work and rehearsals, so she will now take one proper day off every week and go easy in the mornings.
"She has a blood analysis done every few days - including one during last Friday's rehearsal in front of everyone," the source added.