About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Lymph Nodes Instrumental in Spreading Prion Infection

by Medindia Content Team on September 25, 2007 at 8:48 PM
Font : A-A+

Lymph Nodes Instrumental in Spreading Prion Infection

Lymph nodes can be crucial for spreading low doses of infective prion agents -the pathogens responsible for conditions such as scrapie and Creutzfeldt-Jakob disease - into the nervous system, according to new research published in the online open access journal BMC Veterinary Research.

While we can show that the regional lymph node plays no pivotal role in the neuroinvasion of prions for high doses of infection, we cannot rule out the possibility that lymph nodes are still involved in the distribution of prions throughout the body to other non-neural tissues.

Advertisement

The research, carried out by scientists in the group of Michael Beekes at the Robert-Koch Institute in Berlin, Germany, sheds new light on the important issue of how prion agents are transmitted from the site of infection to the brain and spinal cord, where they cause irreparable and fatal damage.

Christine Kratzel and colleagues investigated the role of the lymphoreticular system - which comprises the network of lymph nodes that is part of the body's defence system - in the spread of scrapie infection to nerve tissue in hamsters. The team discovered that if a lymph node close to the site of infection is removed within six days after a high or a medium dose of infective agent has been administered, the animal still develops the disease.
Advertisement

However, if the node is removed 4 weeks before infection, a high dose causes the disease while a low dose does not (over the course of the 314 day time period for the study). The results suggest that for low doses of infective agent the lymphoreticular system is important in facilitating neuroinvasion i.e. the spread of prions from the infection site to the central nervous system.

The team also noted that after a node had been removed and the wound not yet healed, prion infection is substantially accelerated.

The findings are important because the role of the lymphoreticular system and inflammatory processes in the spread of prion infectivity through the body has been poorly understood. A clearer understanding of the factors involved in the transport of the agent in the body will help scientists and doctors to develop new ways of preventing and treating prion diseases.

Source: Eurekalert
LIN/C
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Non-Hodgkins Lymphoma Flu Burkitt’s Lymphoma Swollen Glands Swollen Lymph Nodes Lymphedema Inflammatory Breast Cancer Bubonic Plague Castleman Disease (CD) 

Recommended Reading
New Diagnostic Test for Mad Cow Disease Developed
Scottish scientists have developed a new technique to diagnose mad cow disease in humans. ......
Bubonic Plague
Bubonic plague is an infectious disease caused by the bacteria Yersinia pestis present in rodents an...
Burkitt’s Lymphoma
Burkitt’s lymphoma is a rare type of non-hodgkin’s lymphoma that commonly affects children. It usual...
Castleman Disease (CD)
Castleman disease (CD) is a rare but benign condition in which there is lymph node enlargement. It c...
Inflammatory Breast Cancer
One of the rare breast cancers, inflammatory breast cancer is marked by redness, swelling and warmth...
Lymphedema
Lymphedema is commonly caused by the removal of or damage to the lymph nodes as a part of cancer tre...
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
Swollen Glands
Swollen lymph nodes/ Lymphadenopathy is a condition where lymph nodes that are present throughout th...
Swollen Lymph Nodes
Swollen lymph nodes refer to enlargement of one or more lymph nodes in the body. The medical term fo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use