Researchers writing in the open access journal BMC Cancer have said that the genes that may contribute to drug resistance in non-small cell lung cancer (NSCLC) can now be predicted. They have found good correlation between genes believed to be involved in drug sensitivity and resistance and actual in vitro chemosensitivity.
Ian Cree, from Queen Alexandra Hospital, Portsmouth, UK, led a team of researchers who assessed the chemosensitivity of a series of 49 NSCLC tumors and compared this with quantitative expression of putative resistance genes measured by RT-PCR. He said, "There was considerable heterogeneity between tumors, and while this showed no direct correlation with individual gene expression, there was strong correlation of multi-gene signatures for many of the single chemotherapy agents and combinations tested. This may allow the definition of predictive signatures to guide individualized chemotherapy in lung cancer".
Lung Cancer - Types, Causes, Symptoms, Diagnosis, Treatment and Prevention
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.
When these results were compared to the gene expression in the tumors, Cree and his colleagues were able to identify a number of patterns, especially in chemosensitivity to combinations of treatments. Cree said, "The genes identified in this study fall into several categories, linked with much studied mechanisms such as metabolism within the cell, membrane drug pumps, and DNA repair, but also with apoptosis, suggesting that the general susceptibility of the cell to undergo this process may be an important determinant of tumor chemosensitivity, outweighing more specific mechanisms".
Health Hazards of Smoking Cigarettes
Smoking causes many diseases and affects the overall health of smokers.
Smoking causes many diseases and affects the overall health of smokers.
TAN
Lung Biopsy - Indications - Procedures - Risks - FAQs - Reference
The procedure by which tissue samples are obtained from the lung is known as lung biopsy. The biopsy tissues obtained from the lungs are examined by a pathologist.
The procedure by which tissue samples are obtained from the lung is known as lung biopsy. The biopsy tissues obtained from the lungs are examined by a pathologist.
Mesothelioma
Animation on mesothelioma - a form of lung cancer, that explains about the condition, its risk factors, diagnosis and treatment
Animation on mesothelioma - a form of lung cancer, that explains about the condition, its risk factors, diagnosis and treatment
