Several studies have shown that living donor liver transplant (LDLT) recipients required smaller doses of tacrolimus compared with deceased donor liver transplant (DDLT) patients, which indicated that liver regeneration could affect the metabolism of tacrolimus in LDLT. In recent years, living donor liver transplantation in adult patients with SFS liver grafts has become increasingly accepted. However there are few studies in the existing literature on tacrolimus dosage requirements in LDLT with SFS grafts which require adequate liver regeneration. A research article to be published on Augut 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Li from the Center of Liver Transplantation of Sichuan University collected the medical data from the Center of Liver Transplantation in West China Hospital of Sichuan University, which is one of the biggest centers for liver transplantation in China, to study tacrolimus dosage requirements and blood levels in LDLT recipients with SFS grafts. Previous studies have indicated a high variability of the optimal tacrolimus dose in LDLT. The current article further investigates the tacrolimus dosing requirements in SFS graft by comparing tacrolimus dosage requirements in patients who received a graft with adequate hepatic mass (Group N) and in patients who received a SFS graft (Group S) in LDLT. The result of their study revealed that there was no difference in demographic characteristics, acute rejection rates, liver and renal function test results, or the number of potentially interacting medications administered between the groups. Moreover, Professor Li and colleagues recommended that relatively low tacrolimus doses should be administered to patients who receive living donor liver transplantation with SFS liver grafts. The tacrolimus dosage requirements and blood levels in LDLT with SFS grafts were reported by Professor Li and colleagues in China, which have been previously neglected. These results demonstrate that low doses of tacrolimus may be required in SFS grafts in living donor liver transplantation, which will be a good guideline to follow for rational administration of tacrolimus in future LDLT recipients with SFS grafts.Source: EurekalertLIN << Lymphadenectomy Improves Survival for Patients With Node-Po... Scientists Develop Gene Therapy Method to Prevent Some Inhe... >> Recommended Reading Tacrolimus This medication is an immunosuppressant, prescribed for preventing organ rejection during transplantation. It decreases the activity of immune system to prevent an organ from ... READ MORE Toxic Immune-suppressing Drugs in Monkeys can be Replaced by Post-transplant Combo New findings indicate that the class of immunosuppressive drugs known as calcineurin inhibitors can damage patients' kidneys and lead to high blood pressure in transplant patients. READ MORE Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Liver Transplantation Liver transplantation is a surgical option for the treatment of liver failure where the diseased liver is replaced with a healthy one. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Transplantation Organ and tissue transplantation can give a second chance at life to thousands of people. Learn more about this interesting procedure. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Sanatogen Noscaphene (Noscapine) Find a Hospital More News on: Alcoholic Liver DiseaseHepatitis ALiver TransplantationLiverWilson's DiseaseTransplantationMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?