Lower Mammographic Tumor Detectability for Women in Their 40s

Mammographic screening for in women their forties is not that effective due to lower detectability and not faster tumor growth rate, A study has revealed.

Mammography screening outcomes, measured in terms of tumor size, lifetime gained and mortality, have typically been poorer in women in their forties than women in their fifties, partly because tumors of younger women tend to grow more quickly, so by the time they grow to a detectable size, they would have likely already been detected by a routine examination. Younger women also tend to have denser breast tissue, which can mask tumors, reducing their detectability on mammograms.

Study Details Interventions to Promote Repeat Breast Cancer Screening With Mammography
Study shows that there is no one single intervention that is best for women who can potentially benefit from repeat mammography screening

To investigate which factor—faster tumor growth rates, or reduced mammographic detectability—contributes to poorer mammography screening outcomes in younger women, Sylvia K. Plevritis of the Department of Radiology at the Stanford University School of Medicine, and colleagues, used a computer simulated model to estimate the relative effect of biology and technology on mammograms of women in their forties, compared to women in their fifties and sixties.

The researchers used the Breast Cancer Screening Simulator to create hypothetical screening scenarios whereby they could estimate the median tumor size detectable on a mammogram and the mean tumor growth rate in women aged 40-49 and 50-69.

The researchers concluded from their simulation model that lowered mammographic tumor detectability accounted for 79% and faster tumor volume doubling time accounted for 21% of the poorer sensitivity in mammography screening among younger women, compared with older women.

Less Radiation from Digital Mammography Than Conventional Mammography
Statistics taken from one of the largest mammography trials in history shows that overall the radiation dose connected with digital mammography is markedly lower than conventional mammography.

The authors write, "The age-specific differences in mammographic tumor detection contribute more than age-specific differences in tumor growth rates to the lowered performance of mammography screening in younger women."

One limitation of the analysis, according to the authors, is that it did not take into account that low mammographic tumor detectability could be considered a breast cancer risk factor. They write: "More research is needed to not only establish a better relationship between mammographic breast density and breast cancer risk but also understand the differences in tumor characteristics in dense vs non-dense breast tissue."

Mammography Software may Reduce Number of Missed Breast Cancer Cases
One of Britain's leading biomedical scientists says, NHS can save hundreds of lives each year by adopting a computerised technique for breast cancer screening.

Source-Eurekalert

Study Finds Cognitively Impaired Elderly Women Get Unnecessary Screening Mammography
Study finds a significant percentage of U.S. women 70 years or older who were severely cognitively impaired received screening mammography that was unlikely to benefit them