Metformin, the drug prescribed as part of the diabetes treatment lowers the risk of developing certain cancers and dying from these diseases in post-menopausal women reports a large prospective study from researchers at Roswell Park Cancer Institute (RPCI) and the University at Buffalo (UB).
Their analysis was based on data from the Women's Health Initiative (WHI), a series of large studies undertaken to address common health issues in women. The researchers also found that women with diabetes, compared to women without the disease, were more likely to develop cancer. The team's findings were published in the International Journal of Cancer.
The research effort was led by Zhihong Gong, PhD, Assistant Professor of Oncology in the Department of Cancer Prevention and Control at Roswell Park, and Jean Wactawski-Wende, PhD, one of the principal investigators of the Women's Health Initiative and Dean of the School of Public Health and Health Professions at the University at Buffalo.
Compared to women without diabetes, women with diabetes had a 13% higher risk of developing invasive cancer. These women also face increased risk that ranges from 20% to nearly double the chances of being diagnosed with the following cancers: colon, liver, pancreas, endometrial and non-Hodgkin lymphoma. Results also show that metformin use was associated with better survival in diabetes patients diagnosed with ovarian, colorectal and breast cancer.
"In this large prospective study with long-term follow-up, we examined the association of diabetes and medications to treat the disease with the risk of cancer and cancer mortality overall and by cancer site," says Dr. Gong. "Our findings suggest that diabetes remains a risk factor for cancer overall and increases the risk of certain cancers. But we also found a lower cancer risk for certain cancers among those patients who have used metformin for many years."
"The Women's Health Initiative continues to offer thoughtful, meaningful data to researchers seeking to answer health care questions that impact our understanding of long-term health in older women," says Dr. Wactawski-Wende.
The researchers say future studies are needed to further clarify the long-term impact of metformin on cancer risk and survival.