About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Lower Back Disease may be Genetic

by Rathi Manohar on February 4, 2011 at 8:40 AM
Font : A-A+

 Lower Back Disease may be Genetic

Symptomatic lumbar disc disease caused by degeneration of the discs of the lower spine could be inherited, indicates a new study.

"The results of this study provide evidence based on a population of more than 2 million people, indicating that there likely is a genetic component in the development of this disease. Additionally, the factors that differentiate a symptomatic disc from a non-painful disc may also be affected by genetics," said study author Alpesh A. Patel, FACS, assistant professor of orthopaedic surgery at the University of Utah School of Medicine.

Advertisement

Study Details:

The researchers used data contained in the Utah Population Database, a public information repository containing health and genealogic data of more than 2 million Utah residents, examining health and family records of 1,264 individuals with lumbar disc disease, defined as either lumbar disc degeneration or lumbar disc herniation.
Advertisement

To measure how closely patients were related, the researchers used the Genealogical Index of Familiaity, which compares the average relatedness of affected individuals with expected relatedness in the general population. Relatedness is measured by generations or degrees:

first-degree relatives (or immediate family) including parents, offspring and siblings;

second-degree including grandchildren, grandparents, uncles, aunts, nieces, nephews, and half-siblings; and

third-degree comprising great-grandchildren, great-grandparents, great-aunts and great-uncles, grandnieces and grandnephews and first cousins.

In this study, only patients with at least three generations of genealogical data in the database were included.

The researchers also determined and calculated the Relative Risk (RR) for relatives. This measure defines the risk of lumbar disc disease among family members of patients compared to individuals without disease. Important Findings:

Individuals with lumbar disc disease were more likely to have family members with disc disease.

Relative risk for lumbar disc disease was significantly elevated in both close and distant relatives.

The combination of the two findings, given the large patient population, strongly supports a genetic basis to symptomatic lumbar disc disease.

"Although excess risk in the immediate family might indicate evidence of a genetic contribution, it could also simply indicate shared environment risks or household exposure that may be contributing to the disease," Patel noted.

The study has been published in the Journal of Bone and Joint Surgery (JBJS).

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Genetics and Stem Cells Neck Cracking 

Most Popular on Medindia

Drug - Food Interactions Diaphragmatic Hernia Daily Calorie Requirements A-Z Drug Brands in India Blood Donation - Recipients Indian Medical Journals Hearing Loss Calculator Nutam (400mg) (Piracetam) Iron Intake Calculator Sanatogen
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Lower Back Disease may be Genetic Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests