About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Low Vitamin D Elevates Heart Disease Risk in Diabetes Patients

by VR Sreeraman on August 23, 2009 at 11:05 AM
Font : A-A+

 Low Vitamin D Elevates Heart Disease Risk in Diabetes Patients

A new study has revealed that low levels of sunshine vitamin can almost double heart disease risk in diabetes patients.

Researchers at Washington University School of Medicine in St. Louis have found that diabetes patients with vitamin D deficiency are unable to process cholesterol normally, so it builds up in their blood vessels, thereby increasing the risk of heart attack and stroke.

Advertisement

They have also identified a mechanism linking low vitamin D levels to heart disease risk and may lead to ways to fix the problem, simply by increasing levels of vitamin D.

"Vitamin D inhibits the uptake of cholesterol by cells called macrophages," said principal investigator Dr Carlos Bernal-Mizrachi, a Washington University endocrinologist at Barnes-Jewish Hospital.
Advertisement

"When people are deficient in vitamin D, the macrophage cells eat more cholesterol, and they can't get rid of it.

"The macrophages get clogged with cholesterol and become what scientists call foam cells, which are one of the earliest markers of atherosclerosis," Bernal-Mizrachi added.

The team reports that vitamin D regulates signaling pathways linked both to uptake and to clearance of cholesterol in macrophages.

"Cholesterol is transported through the blood attached to lipoproteins such as LDL, the 'bad' cholesterol," Bernal-Mizrachi explains.

"As it is stimulated by oxygen radicals in the vessel wall, LDL becomes oxidated, and macrophages eat it uncontrollably. LDL cholesterol then clogs the macrophages, and that's how atherosclerosis begins," he added.

That process becomes accelerated when a person is deficient in vitamin D. And people with type 2 diabetes are very likely to have this deficiency.

The findings appear in the journal Circulation.

Source: ANI
SRM
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
Emotional Healing
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Calcium and Vitamin Supplements Diabetic Retinopathy Diabetes Diabetic Diet Rickets Vitamin Supplements Vitamin C / Ascorbic acid Vitamin B6 Vitamin B9 Vitamin B-12 

Recommended Reading
Gestational diabetes
The condition is not caused by a lack of insulin, but by the action of hormones produced during ......
Insulin Delivery Devices
Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed ...
Calcium and Vitamin Supplements
Calcium and vitamin supplements are taken to provide the body with the ''required'' nutrients. ......
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, sy...
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nut...
Diabetic Retinopathy
The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with ......
Rickets
Encyclopedia section of medindia explains in brief about Rickets...
Vitamin B-12
Vitamin B-12 is also known as cobalamine or cyanocobalamine, owing to the presence of the metal, cob...
Vitamin B6
Vitamins play an equally important part in the synthesis of neurotransmitters. Neurotransmitters in ...
Vitamin B9
Vital info about vitamin B9, its molecular structure, dietary sources, beneficial aspects, symptoms ...
Vitamin C / Ascorbic acid
Vital info about vitamin C, its molecular structure, dietary sources, beneficial aspects, symptoms o...
Vitamin Supplements
Easy to understand info & tips with diagrams about vitamin supplements like vitamin C, B6, B9 & B12....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use