A new treatment for post traumatic stress disorder tested in mice shows that injecting adiponectin, which is secreted by fat cells called adipocytes - was found to decrease fear. People who have low levels of a fat hormone might be more prone to developing post-traumatic stress disorder (PTSD) symptoms if they are exposed to a traumatic event. The experimental model, mice were trained to associate a setting, such as a box, with a mild unpleasant stimulus. As expected, they showed a fear response when re-exposed to the setting. ‘People who have low levels of a fat hormone might be more prone to developing post-traumatic stress disorder (PTSD) symptoms if they are exposed to a traumatic event.’ Mice deficient for adiponectin and its receptor formed fearful memories just like healthy mice, but when placed again in the same setting minus the unpleasant stimulus, were slower to let go of the fear. Injecting adiponectin prior to this training prompted faster learning to overcome fear, the measurements showed. "Once the threat is no longer there, the fear should go away, but in PTSD it keeps flashing back," said study senior author Xin-Yun Lu, professor at School of Medicine, The University of Texas Health Science Centre in the US. "In the PTSD animal model, the circulating adiponectin is low, data suggest. If the genes encoding adiponectin and its receptor are disrupted, the mice extinguish fear responses much slower. If adiponectin levels are elevated in the brain, the mice get extinction faster," Lu noted. Adiponectin impairment is implicated in metabolic diseases such as obesity and Type-2 diabetes. The new research, published in the journal Molecular Psychiatry, showed the hormone has a role beyond its metabolic control, Lu said. "It is interesting that this hormone promotes fear extinction," Lu said. "Increasing adiponectin levels or activating its specific receptors might facilitate extinction-based exposure treatments for PTSD and other trauma- and stress-related disorders," she noted. Source: IANS << Legibility at Work can Boost Employees Health Zika Virus Transmission from Bloodstream into Fetus Revealed >> Recommended Reading Brown Fat to Fight Flab Around 50 grams of white fat stores 300 kilocalories. In contrast the same amount of brown fat burns 300 kilocalories a day. Such is the magic of this good fat. READ MORE Post Traumatic Stress Disorder Post Traumatic Stress Disorder (PTSD), is a mental condition triggered by a traumatic event. PTSD treatment includes pyschotherapy, behavior therapy and medications. READ MORE Expert Talks on Post Traumatic Stress Disorder (PTSD)- David Kinchin David Kinchin, author and expert on PTSD sheds light on the invisible injury that continues to haunt many who have experienced a significant traumatic event. READ MORE Ecstasy Can Heal Patients With Post Traumatic Stress Disorder (PTSD) The psychoactive drug 3,4- MethyleneDioxy-N-MethylAmphetamine or MDMA is also known as ecstasy. Ecstasy provides more powerful psychotic benefits than any other drug. READ MORE Andropause / Male Menopause Andropause or male menopause causing low libido in a man is due to decreasing level of male hormones, like testosterone. Symptoms of andropause are depression, irritability. READ MORE Cholesterol Cholesterol is produced by the body (liver) and is essential for normal body functioning. READ MORE Cholesterol - The Enigma Chemical The word 'Cholesterol' rings danger bells as soon as it is mentioned. This important chemical is important for the normal metabolism of the body and is dangerous only if present in excess. READ MORE Heart Attack- Lifestyle risks Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed. READ MORE Is Your Man Moody? Women get confused by the behavior of men in their lives. It is time they realize that men too have frequent mood swings. READ MORE Liposuction Liposuction is a cosmetic procedure, which is used to suck out the excess or abnormal fat deposition to give a well-contoured shapely look. READ MORE Palpitations And Arrhythmias Palpitations are unpleasant sensation of one’s own heartbeat. READ MORE Stress and the Gender Divide Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses. READ MORE Most Popular on Medindia Drug Side Effects Calculator A-Z Drug Brands in India Fongitar (Zinc Pyrithionone) More News on: CholesterolPalpitations And ArrhythmiasDiet Lifestyle and Heart DiseaseStress Relief Through Alternative MedicineStress and the Gender DivideCholesterol - The Enigma ChemicalAndropause / Male MenopauseLiposuctionHeart Attack- Lifestyle RisksIs Your Man Moody?