No one diet strategy is consistently better than others for weight loss in the general population. Some studies have suggested variations in people's genetic makeup could make it easier for some to lose weight than others on certain diets.
‘Even a person's genetic makeup or their insulin secretion level is not associated with weight loss.’
Other studies have reported a person's insulin secretion may explain different weight loss.
About 609 overweight adults enrolled in a randomized clinical trial from January 2013 through April 2015 with follow-up through May 2016.
Adults followed either a healthy low-fat or healthy low-carbohydrate diet (interventions); weight change at 12 months and a determination about whether there were significant links between the type of diet and a person's genetic makeup, insulin secretion levels and weight loss (outcomes).
This was a randomized clinical trial (RCT), which allows the strongest inferences to be made about the true effect of an intervention.
However, not all RCT results can be replicated in real-world settings because patient characteristics or other variables may differ from those studied in the RCT.
The authors of the study were Christopher D. Gardner, Ph.D., Stanford University Medical School, Stanford, California, and coauthors.
A person's genetic makeup or insulin secretion level at the start of the study was not associated with effects on weight loss.
The generalizability of the findings may be limited because the study was conducted in a geographic area where many people have attained relatively high education levels and/or have the personal resources to allow them high accessibility to high-quality food options.