Low Dose Vaginal Estriol Gel Aids Recovery From Pelvic Organ Prolapse

Using an ultra low dose of vaginal estriol gel before and after pelvic organ prolapse surgery can improve recovery time and results.

Pelvic organ prolapse is estimated to affect up to one-half of all women, causing pain and interfering with sexual function.

Pelvic Organ Prolapse - Types, Causes, Symptoms, Diagnosis, Treatment & Prevention
Pelvic Organ Prolapse (POP) is the dropping (herniation) of the pelvic organs due to loss of normal support of the muscles of the pelvic floor.

‘Pre-surgery treatment using 0.005% vaginal estriol gel improved vaginal health and related symptoms in women with pelvic organ prolapse. The use of the vaginal gel after surgery additionally improved recovery times and results.’

Tweet it Now

Pelvic organ prolapse

Pelvic organ prolapse, also known as dropped bladder or dropped vagina, is essentially a weakening of the vaginal tissues that causes a descent of a pelvic organ into or beyond the vagina, perineum, or anal canal.

It is typically caused by childbirth, heavy lifting, chronic constipation, or poor tissue and often worsens with age. Multiple treatment options are available, including surgery.

Evaluation of Treatment Options for Pelvic Organ Prolapse
Many women with pelvic prolapse have questions about long-term expectations when choosing between surgery or pessary.

The Italian-based study included 75 women aged 56 to 63 years who had been menopausal between 7 and 14 years. The authors acknowledged that additional studies are necessary to evaluate the long-term efficacy of the vaginal estriol treatment and verify its extended benefits.

Postmenopausal women, whose estrogen levels have dropped and vaginal walls have thinned, are more likely to experience pain during the recovery period after surgery and beyond.

Cause of Pelvic Organ Prolapse Identified
The cause of pelvic organ prolapse is due to the combination of a loss of elasticity and breakdown of proteins that are present in the vaginal wall, says a gynecologist.

Topical estrogens, which absorb rapidly through the vaginal wall and thus can be used at low concentrations, have already proven effective in treating a number of vaginal problems commonly associated with menopause.

The published data from the study, "Effects of ultralow topical estriol dose on vaginal health and quality of life in postmenopausal women who underwent surgical treatment for pelvic organ prolapse," suggests that presurgery treatment using 0.005% vaginal estriol gel improved vaginal health and related symptoms in women with pelvic organ prolapse. The use of the vaginal gel after surgery additionally improved recovery times and results.

Surgery for Pelvic Organ Prolapse is Effective Long-term
After seven years of follow-up, results suggest that women considering abdominal sacrocolpopexy (surgery for pelvic organ prolapse [POP]) should be counseled that this procedure effectively provides relief from POP symptoms.

"Postmenopausal women with urogenital atrophy complain of vaginal dryness and often painful sex that improves with the use of low-dose vaginal estrogen, which is available in the United States as a low-dose vaginal cream, tablet, or ring," says Dr. JoAnn Pinkerton, executive director of NAMS.

"In this study, a vaginal estrogen product that is not available in the United States was tested and shown to improve vaginal health before pelvic floor therapy and to improve sexual health and quality of life if continued after surgery. Another finding was that combining vaginal estrogen with regular sexual activity led to improvement in vaginal health over using vaginal estrogen alone."

Source-Eurekalert