About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Low-calorie Diets and Healthy Ageing - How are They Related?

by Himabindu Venkatakrishnan on March 2, 2015 at 4:35 PM
Font : A-A+

 Low-calorie Diets and Healthy Ageing - How are They Related?

Beneficial effects of low-calorie diets on healthy ageing has been highlighted in a new study. Targeting mechanisms in the central nervous system sense energy generated by nutrients.

The study conducted at Harvard T.H. Chan School of Public Health suggested that Targeting mechanisms in the central nervous system that sense energy generated by nutrients might yield the beneficial effects of low-calorie diets on healthy aging without the need to alter food intake.

Advertisement

The study focused on a molecule called "AMP-activated protein kinase," or AMPK, which acts as a molecular fuel gauge to detect energy levels. It's been known that AMPK plays important roles in all cell types, but researchers didn't understand which of these activities were most critical to regulating longevity.

The researchers found that AMPK inhibited the activity of a protein called CRTC-1 in neurons. This process, in turn, controlled the behavior of mitochondria the primary energy-producing organelles in cells throughout the organism, by altering production of a neurotransmitter. The researchers were struck by the fact that altering the AMPK pathway in just a limited set of neurons was sufficient to override its effects on metabolism and longevity in other tissues. Aging was influenced more by what the animals perceived they were eating than what they actually ate.
Advertisement

The study suggested that manipulating this energy-sensing pathway can cause organisms to perceive their cells to be in a low-energy state, even if they are eating normally and energy levels are high. Drugs targeting the cells' energy-sensors in this way could potentially address age-related diseases, including cancer and neurodegeneration, and may offer an alternative to caloric restriction.

The study is published in the journal Cell.

Source: ANI
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Low-calorie Diets and Healthy Ageing - How are They Related? Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests