About My Health Careers Internship MedBlogs Contact us

Low Birth Rate Babies may Later Develop Chronic Kidney Disease

by Tanya Thomas on November 22, 2008 at 4:30 PM
Font : A-A+

Low Birth Rate Babies may Later Develop Chronic Kidney Disease

The risk of an individual developing segmental glomerulosclerosis, a chronic kidney disease, increases if they had low-birth weights as babies, says a new study.

Usually, kidney specialists taking care of adult patients often overlook birth history. However, patients with focal segmental glomerulosclerosis develop scarring of glomeruli, the filtering units of the kidney. This development can cause a decline in kidney function and leakage of protein into the urine.


Low birth weight of less than 5.5 pounds caused by prematurity or slow growth prior to birth is a risk factor for adult hypertension, coronary heart disease, stroke, diabetes, and other diseases.

In the study, researchers aimed at finding the link between lower birth weight and the risk of developing a condition called secondary focal segmental glomerulosclerosis.

Thus, Vivette D'Agati, MD, of the Columbia University College of Physicians and Surgeons in New York City, NY, and her colleagues studied six patients ie two women and four men who had clinical indications of this condition and who were born prematurely and of a very low birth weight.

The average age of patients was 32 years, and their average birth weight was 3.3 pounds. They all were born between 22 and 30 weeks of gestation, compared with full-term babies who are born between 37 and 42 weeks.

For their study, the researchers performed urine tests that measured whether protein was leaking into the urine and blood tests that indicated how well the patients' kidneys were functioning. They also biopsied the patients' kidneys to analyze the tissue.

After all the measurements and tests, it was found that the patients had developed focal segmental glomerulosclerosis.

The authors noted that because new nephrons-the filtering structures of the kidney-are not formed after birth, an individual's supply of nephrons is dependent on the environment in the uterus prior to birth and the extent of a foetus' growth and development.

In case an individual is born with a deficiency of nephrons, their kidneys may become strained, which can lead to declines in kidney function over time.

This may be the scenario for individuals who were born prematurely and who go on to develop focal segmental glomerulosclerosis.

"Premature babies with very low birth weights may develop renal disease in adolescence or adulthood that is a consequence of retarded kidney development and overwork of the kidney. Doctors need to be aware of this association so that the condition is not misdiagnosed or treated inappropriately," said Dr. D'Agati.

The study will appear in the January 2009 issue of the Clinical Journal of the American Society Nephrology.

Source: ANI

News A-Z
News Category
What's New on Medindia
Fermented Skin Care
Television Binge-Watching May Boost the Risk of Deadly Blood Clots
Western Diet may Augment the Risk of Autoimmune Diseases
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Glomerulonephritis Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis Kidney Biopsy 

Recommended Reading
Glomerulonephritis is used to describe several kidney disease that damage the glomeruli. ......
Kidney Stones
A kidney stone is a solid mass made up of tiny crystals and may appear in any area of the urinary .....
Time Averaged Concentration of Urea
This calculator gives you the average concentration of urea, which is calculated with the value of ...
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Renal Tubular Acidosis
Renal tubular acidosis/RTA results in acid content of the blood being higher than normal and that of...
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain ca...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)