B cell-mediated autoimmune diseases and lymphoma can now be treated using antibodies against B cell protein CD20. Antibody binding receptors, called Fc receptors, on other immune cells bind anti-CD20 on coated B cells, which induces B cell deletion through a mechanism that is not clearly understood. In this issue of the Journal of Clinical Investigation, Philippe Bousse and colleagues at the Pasteur Institute in Paris described the fate of B cells in live mice after treatment with anti-CD20 antibodies. Bousse and his group found that B cells circulating through the liver were the first ones depleted after treatment and that B cells in circulation were more susceptible to deletion than those stationary in the spleen or lymph nodes. The researchers used intravital two-photon microscopy to follow B cells in the liver as they halted near specialized Fc receptor-bearing cells called Kupffer cells. The Kupffer cells bound and consumed the anti-CD20-coated B cells. The study assigns a vital role to liver Kupffer cells in deleting B cells and describes techniques that may be used to improve the effectiveness of anti-CD20Source: Eurekalert << New Study Dismisses Direct Link Between Sugar Intake and Liv... Chronic Epileptic Seizure May Now Be Prevented By Low Frequ... >> Recommended Reading Immunotherapy Showed Promising Antileukemia Activity in Pediatric Patients: Research Researchers using patients' own immune cells in an immunotherapy approach achieved responses in children whose acute lymphocytic leukemia (ALL) had returned after a bone marrow transplant. READ MORE Rationale for Use of Targeted Immunotherapy in Sarcomatoid Lung Carcinomas Highlighted Rare subtypes of poorly differentiated non-small-cell lung carcinomas of high grade and aggressive behavior are observed in sarcomatoid carcinomas of the lung. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Dealing with Pollen Allergy The plants around you that give you sniffles in your nose at specific time of the year are the source of allergy causing pollens. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Calculate Ideal Weight for Infants Turmeric Powder - Health Benefits, Uses & Side Effects The Essence of Yoga More News on: Hepatitis AParkinsons Disease Surgical TreatmentLiverWilson's DiseaseDealing with Pollen AllergyMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?