About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Lithium Treatment for Bipolar Disorder Lowers Risk of Rehospitalisation

by Anjali Aryamvally on March 1, 2018 at 11:17 AM
Font : A-A+

Lithium Treatment for Bipolar Disorder Lowers Risk of Rehospitalisation

Individuals treated with lithium for bipolar disorder had the lowest risk of rehospitalisation, according to a study from Karolinska Institutet in Sweden published in JAMA Psychiatry. Long-acting injections of antipsychotics were also found to be more effective at reducing the risk of rehospitalisation compared with their oral counterparts.

Bipolar disorder is characterised by alternating periods of depression and elevated mood (mania), and is usually treated either with mood stabilising or antipsychotic drugs. Lithium is considered to be the most effective mood stabiliser, but only a few studies have been conducted comparing the long-term effects of different drugs in bipolar disorder.

Advertisement


In order to determine which treatment is most effective, researchers at Karolinska Institutet compared the risk of re-admission to hospital in more than 18,000 patients in Finland who had previously been hospitalised for bipolar disorder. Each patient was used as their own control and compared during periods with and without treatment.

During an average follow-up time of more than seven years, lithium treatment was associated with the lowest risk of rehospitalisation in mental or physical disease, with a risk reduction of about 30 per cent compared with no treatment at all. Long-acting injections of antipsychotic drugs were also effective. The risk of re-admission was around 30 per cent lower if patients were treated with long-acting injections compared to their receiving the same antipsychotic medication but orally. The most commonly prescribed antipsychotic drug for bipolar disorder, quetiapine (Seroquel), which is given in tablet form, reduced the risk by only 7 per cent.
Advertisement

"The prescription of lithium has decreased steadily in recent years, but our results show that lithium should remain the first line of treatment for patients with bipolar disorder. Long-acting injections might offer a safe, effective option for patients for whom lithium is not suitable", says Jari Tiihonen, specialist doctor and professor at Karolinska Institutet's Department of Clinical Neuroscience.

The research was funded by the Finnish Ministry of Social Affairs and Health. No company has financed this particular study, but several of the authors are associated with and have previously received funding/fees from pharmaceutical companies in different contexts. Two of the authors are employed by the contract research organisation EPID Research. The scientific article provides more detailed information about potential conflicts of interest.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Is COVID-19 Vaccination during Pregnancy Safe?
Sensory Processing Disorder (SPD)
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Quiz on Depression Bipolar Disorder Loss of Taste Schizoaffective Disorder Euphoria Social Anxiety Disorder Anosognosia Mood Swings 

Recommended Reading
Autism, Schizophrenia, Bipolar Disorder Share Molecular Traits
Autism, schizophrenia and bipolar disorder share gene activity in brain, revealed new study....
Biology of Bipolar Disorder Explored
New insights into the underlying biology of bipolar disorder (BD) affecting millions of people ......
Early Symptoms and Risk Factors may Help Predict Development of Bipolar Disorder
Two patterns of early symptoms that precede bipolar disorder help predict later development of the ....
Insight on Distinct Origins Of Bipolar Disorder Subtypes
The most common subtypes of bipolar disorder, bipolar I and bipolar II, stem from different ......
Anosognosia
Anosognosia is the lack of awareness or insight in a patient to understand that he/she has a disease...
Bipolar Disorder
Bipolar Disorder is a brain disorder in which people show “mood swings”. Changes in the level of ne...
Euphoria
Euphoria is an exaggerated state of happiness and well-being that is beyond the normal emotional res...
Loss of Taste
Symptom of loss of taste usually occurs in combination with loss of smell and can be complete loss o...
Mood Swings
It is normal to go through mood changes such as joy, sadness or anger every day, but when these mood...
Schizoaffective Disorder
Schizoaffective disorder is a serious mental disorder in which the individual reflects symptoms that...
Social Anxiety Disorder
Social anxiety disorder is a common mental health problem where a person is abnormally fearful of so...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use