About Careers Internship MedBlog Contact us

Listeria Breaches the Placenta Using Enzyme Phosphoinositide-3 Kinase Following Activation by Internalin Proteins

by Dr. Trupti Shirole on January 28, 2015 at 6:31 AM
Font : A-A+

 Listeria Breaches the Placenta Using Enzyme Phosphoinositide-3 Kinase Following Activation by Internalin Proteins

A gut bacterium called Listeria (Listeria monocytogenes), which is often found in soft cheese, is known to present a risk to pregnant women by using distinct tactics to breach the intestine and the placenta, using an enzyme phosphoinositide-3 kinase following activation by internalin proteins, according to researchers at Pasteur Institute in France.

Listeria has two proteins, called internalins A and B, that helps it cross mucosal tissue barriers. Both proteins attach to tissue receptors and are needed for Listeria to invade the placenta, but protein A alone can propel Listeria across the intestine. The underlying cause of these differences remains unknown. Tissue invasion by Listeria also requires the enzyme phosphoinositide-3 kinase (PI3-K), which is turned on by both of the Listeria's internalin proteins, but only the B protein has a built-in activation mechanism.


Researcher Lecuit and his colleagues have been able to visualize the activation of PI3-K, finding that this enzyme is very important for Listeria invasiveness via internalins. They uncovered that PI3-K is perpetually turned on in intestinal cells, using only internalin A and rendering internalin B dispensable, while the placenta has little to no inherent PI3-K activity, which is why passage of the bug through the placenta requires both A and B internalins.

These findings open up new opportunities to examine if other microbes-in addition to those posing a pregnancy risk-are capable of crossing host barriers using PI3-K activation, and whether this mechanism of invasion occurs in other mucosal tissues and organs.

The study is published in 'The Journal of Experimental Medicine'.

Source: Medindia


Recommended Readings

Latest Research News

Is There a Cure for Malaria Through Targeting Biological Clocks?
Malaria parasites sync their molecular rhythms with the internal 24-hour clocks of their hosts, said researchers.
Good Evening Recovery Leads to Better Work Days
A latest research suggests that the quality of a person's post-work recovery in the evening can impact their mood when they resume work the next day.
Link Between Sleep Apnea and Cognitive Decline
Researchers are working on new strategies and solutions for sleep apnea to ward off a range of health risks including cognitive decline.
Softening Stem Cells Enhances Hair Growth Potential
The scientists discovered that when the stem cells in the hair follicle are made softer, they have a higher chance of growing hair.
Potential New Strategy for Ischemic Stroke Discovered
A combinatorial therapy provided promising beneficial results among people with ischemic stroke.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Listeria Breaches the Placenta Using Enzyme Phosphoinositide-3 Kinase Following Activation by Internalin Proteins Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests