About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Liquid Solution Helps Fight Antibiotic-resistant Bacteria

by Sheela Philomena on December 12, 2011 at 12:37 PM
Font : A-A+

 Liquid Solution Helps Fight Antibiotic-resistant Bacteria

An efficient and cost-effective liquid solution has been developed by researchers to fight antibiotic-resistant bacteria and keep hospitals safe from infections.

The solution, developed by Udi Qimron of the Department of Clinical Microbiology and Immunology at Tel Aviv University's Sackler Faculty of Medicine, is based on specially designed bacteriophages, viruses that infect bacteria, which can alter the genetic make-up of antibiotic-resistant bacteria.

Advertisement

"We have genetically engineered the bacteriophages so that once they infect the bacteria, they transfer a dominant gene that confers renewed sensitivity to certain antibiotics," Qimron said.

Certain antibiotics are designed to target and bind to a part of the bacteria cell called a ribosome, which is the protein factory of the cell. But after continual and frequent exposure to antibiotics, the bacteria "learn" to change components in the ribosome itself so that the antibiotics are unable to bind.
Advertisement

Qimron and his colleagues set out to determine whether they could make resistant bacteria sensitive to antibiotics again by re-introducing a component of the ribosome, a gene called rpsL, which restores bacteria's sensitivity to antibiotics.

"Our novel approach relies on an effective delivery process and selection procedure, put on the same platform for the first time," he said.

With this system, the sensitive bacteria take over the ecological niche once occupied by the resistant bacteria. And if a patient does happen to become infected by lingering bacteria anyway, traditional antibiotics can again be used as an effective treatment.

Added to cleansers, Tellurite represents the second step in a two-part process. A Tellurite compound, which is toxic to bacteria, would also be spread on all surfaces to wipe out the bacteria that had not been rendered sensitive, and thus the entire population of the surface bacteria would be sensitized.

The combination is designed to first disarm, and then kill dangerous bacteria.

Next, the solution will be tested in pre-clinical animal trials to ensure its safety before being made available for wider use at hospitals.

According to Qimron, once the safety of the solution is guaranteed, the solution will come in a bottle and easily added to a bucket or spray.

The solution has been detailed in the journal Applied and Environmental Microbiology.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Shigellosis MRSA - The Super Bug 

Most Popular on Medindia

Calculate Ideal Weight for Infants Sinopril (2mg) (Lacidipine) Vent Forte (Theophylline) Sanatogen Post-Nasal Drip Drug Side Effects Calculator A-Z Drug Brands in India Pregnancy Confirmation Calculator Noscaphene (Noscapine) Indian Medical Journals
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Liquid Solution Helps Fight Antibiotic-resistant Bacteria Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests