The way in which high glucose levels drive diabetes-associated complications, including retinopathy, neuropathy, and nephropathy, is not well-understood. There is evidence that cultured cells exposed to high levels of glucose produce reactive oxygen species (ROS); however it is unknown if ROS contributes directly to diabetes complications. In this issue of the Journal of Clinical Investigation, Kumar Sharma and colleagues at the University of California, San Diego determined that ROS production was actually reduced in kidneys of diabetic mice, and this decrease was associated with lowered activity of the major energy-sensing enzyme, AMPK. Furthermore, AMPK activity was also reduced in kidneys of diabetic patients. Treatment of diabetic mice with a compound that increased AMPK activity reduced kidney-associated symptoms, including fibrosis and albuminuria. In the companion commentary, Dwight Towler of the Sanford-Burnham Medical Institute discusses how this view of ROS in diabetes will require a new look at therapeutic approaches for relieving diabetes complications. Source: Eurekalert << Substandard Housing Takes Toll on Children of Low-Income Fa... Patients' Response to Inhaled Bronchodilators in COPD Influ... >> Recommended Reading Diabetes - Foot Care Valuable information on diabetic foot care, treatment and prevention. READ MORE Diabetic Diet The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nutrients, but low in fat (especially saturated fat) and moderate in calories. READ MORE Gestational diabetes The condition is not caused by a lack of insulin, but by the action of hormones produced during pregnancy that blocks the action of insulin. READ MORE Diabetes A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, symptoms, diagnosis, treatment, facts and a glossary on diabetes. READ MORE Diabetes - Essentials Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels and several associated complications if left untreated. READ MORE Diabetes - Self-Monitoring of Blood Glucose (SMBG) Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Diabetes. READ MORE Diabetes and Exercise Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the demand for medication by 20% and helps you stay healthy. READ MORE Diabetic Retinopathy The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with diabetes. READ MORE Insulin Delivery Devices Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed to provide insulin to the patients with minimal discomfort. READ MORE Stress and the Gender Divide Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses. READ MORE Most Popular on Medindia Fongitar (Zinc Pyrithionone) Calculate Ideal Weight for Infants Nutam (400mg) (Piracetam) More News on: Diabetic RetinopathyDiabetesDiabetic DietDiabetes - EssentialsDiabetes - Self-Monitoring of Blood Glucose (SMBG)Insulin Delivery DevicesDiabetes and ExerciseStress Relief Through Alternative MedicineStress and the Gender DivideSilent Killer Diseases
The way in which high glucose levels drive diabetes-associated complications, including retinopathy, neuropathy, and nephropathy, is not well-understood. There is evidence that cultured cells exposed to high levels of glucose produce reactive oxygen species (ROS); however it is unknown if ROS contributes directly to diabetes complications. In this issue of the Journal of Clinical Investigation, Kumar Sharma and colleagues at the University of California, San Diego determined that ROS production was actually reduced in kidneys of diabetic mice, and this decrease was associated with lowered activity of the major energy-sensing enzyme, AMPK. Furthermore, AMPK activity was also reduced in kidneys of diabetic patients. Treatment of diabetic mice with a compound that increased AMPK activity reduced kidney-associated symptoms, including fibrosis and albuminuria. In the companion commentary, Dwight Towler of the Sanford-Burnham Medical Institute discusses how this view of ROS in diabetes will require a new look at therapeutic approaches for relieving diabetes complications. Source: Eurekalert << Substandard Housing Takes Toll on Children of Low-Income Fa... Patients' Response to Inhaled Bronchodilators in COPD Influ... >> Recommended Reading Diabetes - Foot Care Valuable information on diabetic foot care, treatment and prevention. READ MORE Diabetic Diet The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nutrients, but low in fat (especially saturated fat) and moderate in calories. READ MORE Gestational diabetes The condition is not caused by a lack of insulin, but by the action of hormones produced during pregnancy that blocks the action of insulin. READ MORE Diabetes A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, symptoms, diagnosis, treatment, facts and a glossary on diabetes. READ MORE Diabetes - Essentials Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels and several associated complications if left untreated. READ MORE Diabetes - Self-Monitoring of Blood Glucose (SMBG) Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Diabetes. READ MORE Diabetes and Exercise Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the demand for medication by 20% and helps you stay healthy. READ MORE Diabetic Retinopathy The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with diabetes. READ MORE Insulin Delivery Devices Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed to provide insulin to the patients with minimal discomfort. READ MORE Stress and the Gender Divide Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses. READ MORE Most Popular on Medindia Fongitar (Zinc Pyrithionone) Calculate Ideal Weight for Infants Nutam (400mg) (Piracetam) More News on: Diabetic RetinopathyDiabetesDiabetic DietDiabetes - EssentialsDiabetes - Self-Monitoring of Blood Glucose (SMBG)Insulin Delivery DevicesDiabetes and ExerciseStress Relief Through Alternative MedicineStress and the Gender DivideSilent Killer Diseases