Gene variations in a particular gene called single nucleotide polymorphisms (SNPs) lowers the survival rate of patients with early onset of breast cancer, reveals a new study.
Breast cancer is the second leading cause of cancer-related death in women, with nearly 450,000 deaths per year from the disease worldwide. However, women aged 15-39 at diagnosis have a poorer chance of surviving their cancer than older women* (although survival rates for the disease are generally high).
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‘Understanding the genes and pathways can help develop new therapies for breast cancer.’
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This difference is partly due to the higher incidence of adverse tumor types that occur in younger women, but age is an independent risk factor even after accounting for differences in tumor type and treatment. The new study was led by scientists at the University of Southampton.
The Southampton study is one of the largest ever undertaken into the link between genes and breast cancer survival in women aged 40 or under at diagnosis looked at which factors, other than the features of the cancer tissue, might contribute to the poorer survival rate in younger women.
![Screening for Breast Cancer with Clinical Breast Examination]( "Screening for Breast Cancer with Clinical Breast Examination")
Clinical breast examination is a simple and inexpensive method of detecting breast cancer especially in women who do not have access to mammography.
Scientists discovered that variations called single nucleotide polymorphisms (SNPs) in a particular gene, ADAMTSL1, increased the risk of disease progression - but only in patients with early onset of the disease.
SNPs describe locations in the genome (a person's entire genetic instructions) where a single nucleotide of the DNA sequence may vary among individuals. Studies such as this look for a link between this type of genetic variation and survival.
The collaborative study is published in the journal Nature Communications. Lead author Dr William Tapper said that the findings could eventually be used to improve the accuracy of estimates of disease progression, helping clinicians and patients to choose the most effective treatments.
"This is a significant discovery with exciting implications for the future diagnosis and treatment of early-onset breast cancer patients," said Dr Tapper.
"Our findings increase our understanding of the genes and pathways that are involved in breast cancer prognosis, and may provide new targets for the development of novel therapies."
"In the short to medium-term, this genetic factor may be used to improve prognostic models. In the long-term, when more is known about the mechanism underlying this association and its relationship with treatment response, it may have an influence on approaches to the most effective breast cancer treatments."
Dr Tapper added that additional studies would be needed to fully investigate the findings and their implications.
Source: Eurekalert
Screening for Breast Cancer with Clinical Breast Examination
Clinical breast examination is a simple and inexpensive method of detecting breast cancer especially in women who do not have access to mammography.
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Scientists discovered that variations called single nucleotide polymorphisms (SNPs) in a particular gene, ADAMTSL1, increased the risk of disease progression - but only in patients with early onset of the disease.
SNPs describe locations in the genome (a person's entire genetic instructions) where a single nucleotide of the DNA sequence may vary among individuals. Studies such as this look for a link between this type of genetic variation and survival.
The collaborative study is published in the journal Nature Communications. Lead author Dr William Tapper said that the findings could eventually be used to improve the accuracy of estimates of disease progression, helping clinicians and patients to choose the most effective treatments.
"This is a significant discovery with exciting implications for the future diagnosis and treatment of early-onset breast cancer patients," said Dr Tapper.
"Our findings increase our understanding of the genes and pathways that are involved in breast cancer prognosis, and may provide new targets for the development of novel therapies."
"In the short to medium-term, this genetic factor may be used to improve prognostic models. In the long-term, when more is known about the mechanism underlying this association and its relationship with treatment response, it may have an influence on approaches to the most effective breast cancer treatments."
Dr Tapper added that additional studies would be needed to fully investigate the findings and their implications.
Source: Eurekalert
Triple-Negative Breast Cancer
Triple-negative breast cancers are ER negative, PR negative, and lack overexpression of HER-2. They are difficult to treat and are very aggressive.
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 Breast CancerBreast cancer is a cancer that affects the breasts or mammary glands. Early detection and lifestyle changes help in controlling breast cancer. | Advertisement
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