About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Link Between Chronic Pain and Anxiety Identified

by Shirley Johanna on September 1, 2016 at 7:57 PM
Font : A-A+

Link Between Chronic Pain and Anxiety Identified

Increased expression a peptide neurotransmitter, PACAP, may be a good target for both chronic pain and anxiety disorder, according to a new study by researchers at Vermont. PACAP is a peptide neurotransmitter the body releases in response to stress.

The researchers examined the expression of PACAP (pituitary adenylate cyclase activating polypeptide) along one of the nervous system's pathways to the brain - the spino-parabrachiomygdaloid tract - which travels from the spinal cord to the amygdala, the brain's home base for emotional behavior.

Advertisement


Using models for chronic pain and anxiety, as well as models that can trace PACAP neurocircuits, the team members were able to observe where the stress and chronic pain pathways intersected.

"Chronic pain and anxiety-related disorders frequently go hand-in-hand," says senior author Victor May, Ph.D., professor of neurological sciences at the University of Vermont (UVM). In a 2011 study, he and members of the research team found that PACAP was highly expressed in women exhibiting PTSD symptoms.
Advertisement

While May and his colleagues saw an increase in anxiety-related behaviors in models of chronic pain, the anxious behavior and pain hypersensitivity were significantly reduced when a PACAP receptor antagonist - designed to block the response - was applied.

"By targeting this regulator and pathway, we have opportunities to block both chronic pain and anxiety disorders," says May, whose next step is to work with University of Vermont chemistry colleagues to develop small molecule compounds that can antagonize PACAP actions.

"This would be a completely different approach to using benzodiazepine and opioids - it's another tool in the arsenal to battle chronic pain and stress-related behavioral disorders."

The study's findings are published in the Biological Psychiatry.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Anxiety Disorder Agoraphobia Aspergerīs Syndrome Stress Relief Through Alternative Medicine Hyperventilation Bereavement Post Traumatic Stress Disorder Xenophobia Tourette Syndrome Placebo Effects: Rare Insights 

Most Popular on Medindia

Accident and Trauma Care Color Blindness Calculator Sanatogen Diaphragmatic Hernia Daily Calorie Requirements Drug Interaction Checker Find a Hospital Find a Doctor Nutam (400mg) (Piracetam) Drug - Food Interactions
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Link Between Chronic Pain and Anxiety Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests