Researchers have identified a strong association between amyloid beta peptide levels and Alzheimer's disease.
"We have found that after several injections with LPS toxin, (seven consecutive days of LPS administration) mice showed significant elevation in Aβ levels in their brains," said Michael Chumley, assistant professor of biology at Texas Christian University in Fort Worth. "This elevation corresponds with a decreased ability to learn simple tasks."
Alzheimers Disease
Alzheimer''s disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.
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Scientists have long thought that inflammation might stimulate the onset of Alzheimer's or other cognitive diseases. It is well known that one of the things that cause inflammation in the brain is Aβ plaques, which are produced in response to inflammation. This leads to a self-perpetuating inflammation, where the product of inflammation leads to more inflammation. Scientists continue to research just how these Aβ plaques cause inflammation that leads to diminished brain function.
"What is unique in our study is that we initiated the inflammation in the body of the animal and not in the brain, and it lead to both an elevation of Aβ in the brain and learning deficits," said Chumley. "Our next step will be to determine if it is the Aβ produced in response to the inflammation that is the cause of the short-term memory problems."
![Quiz On Alzheimer’s Disease]( "Quiz On Alzheimer’s Disease")
Alzheimer's disease (AD) is the most common form of dementia. Participate in this quiz to find out how much you know about this debilitating disease.
"In over 90% of all Alzheimer's disease cases, the so called sporadic AD, the cause is unknown. It is likely that many factors, including genetic, environmental, etc., play a role in the onset of AD. We believe that peripheral inflammation (inflammation outside of the brain and spinal cord), may also be one of these factors," said Chumley.
This research was published in Journal of Behavioural Brain Research in January 2012.
Source: Eurekalert
Quiz On Alzheimer’s Disease
Alzheimer's disease (AD) is the most common form of dementia. Participate in this quiz to find out how much you know about this debilitating disease.
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"In over 90% of all Alzheimer's disease cases, the so called sporadic AD, the cause is unknown. It is likely that many factors, including genetic, environmental, etc., play a role in the onset of AD. We believe that peripheral inflammation (inflammation outside of the brain and spinal cord), may also be one of these factors," said Chumley.
This research was published in Journal of Behavioural Brain Research in January 2012.
Source: Eurekalert
Caring for Alzheimers disease patients
Alzheimer's disease is a complex brain disorder that triggers the most common form of dementia. The slide show will show how patients need support and care as dementia progresses.
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 Risk Factors for Alzheimers DiseaseCognitively normal adults exhibiting atrophy of their temporal lobe or damage to blood vessels in the brain are more likely to develop Alzheimer's disease. | Advertisement
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