Recent study provides fresh insight into the mechanism associated with the survival of leukemia stem cells. This finding could pave way for novel leukemia treatments.

Strategies targeting leukemia stem cells are necessary to achieve a cure. Previous work has implicated the enzyme sirtuin 1 (SIRT1) in protecting stem cells from stress and in playing a role in leukemia, as well as other types of cancer. In the current study, Dr. Bhatia, coauthor Dr. WenYong Chen, first author Ling Li, and their colleagues investigated whether SIRT1 was involved in the survival and growth of CML stem cells. The researchers discovered that SIRT1 was overexpressed in CML stem cells and that inhibition of SIRT1selectively reduced the survival and growth of CML stem cells. Importantly, SIRT1 inhibition was associated with activation of the p53 tumor suppressor.
Taken together, the results reveal a specific mechanism that supports the survival of leukemia stem cells. "Our findings are important because they show that SIRT1-mediated inactivation of p53 contributes to CML leukemia stem cell survival and resistance to treatment with tyrosine kinase inhibitors," concludes Dr. Chen. "We suggest that SIRT1 inhibition is an attractive approach to selectively target leukemia stem cells that resist elimination by current treatments."
Source-Eurekalert