Well Known Blood Clotting Drug may Help Regulate Body Weight
Heparin (blood thinner) can potentially be a target for treating eating disorders, including overeating, a leading cause of obesity in the world.
Heparin (blood thinner) can potentially be a target for treating eating disorders, including overeating, a leading cause of obesity in the world.
‘Protein tyrosine phosphatase receptor type J plays critical roles in the development of leptin resistance. The inhibition of PTPRJ may be a potential strategy for improving obesity.’
Tweet it Now
The research group of Professor Masaharu Noda, Associate Professor Takafumi Shintani, and a graduate student Satoru Higashi of the National Institute for Basic Biology (NIBB) demonstrated that protein tyrosine phosphatase receptor type J (PTPRJ) inhibits leptin signaling and that induction of PTPRJ in the hypothalamus is a cause of leptin resistance. They showed that PTPRJ is expressed in hypothalamic neurons together with leptin receptors, and that PTPRJ inhibits activation of the leptin receptor through dephosphorylation of JAK2, a protein tyrosine kinase associated with the leptin receptor. Ptprj-deficient (Ptprj-KO) mice showed no growth retardation, but exhibited lower weight gain, because of a lower food intake and a lower adiposity, than wild-type (WT) mice.
Importantly, PTPRJ expression in the hypothalamus was up-regulated by diet-induced obesity, and, thus, diet-induced leptin resistance did not occur in Ptprj-KO mice. Furthermore, the overexpression of PTPRJ in the hypothalamus induced leptin resistance in lean mice. These results strongly indicate that PTPRJ plays critical roles in the development of leptin resistance. The inhibition of PTPRJ may be a potential strategy for improving obesity.
Exercise May Not Always Facilitate Body Weight Control
If you already have a pretty great sex life, try incorporating few exercises and stretches into your workout routine and reap the benefits in the bedroom.
If you already have a pretty great sex life, try incorporating few exercises and stretches into your workout routine and reap the benefits in the bedroom.
Lower Body Weight in Late Life may Increase Risk of Alzheimer's Disease
Having a lower BMI was associated with more extensive amyloid deposits in the brain in normal adults, posing a risk of Alzheimer's disease.
Having a lower BMI was associated with more extensive amyloid deposits in the brain in normal adults, posing a risk of Alzheimer's disease.
Cheat Day Helps Dieters Achieve Body Weight-related Goals
Planning “hedonic deviations,” or giving in to your impulse to eat a fatty meal can actually help you stay motivated and stick to your goals.
Planning “hedonic deviations,” or giving in to your impulse to eat a fatty meal can actually help you stay motivated and stick to your goals.
