About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

LDL Cholesterol-Lowering Therapy can Reduce Risk of Heart Disease, Stroke in Kidney Disease Patients

by Bidita Debnath on May 4, 2014 at 12:24 AM
Font : A-A+

 LDL Cholesterol-Lowering Therapy can Reduce Risk of Heart Disease, Stroke in Kidney Disease Patients

Through statin-based treatment, lowering LDL cholesterol did not slow kidney disease progression within five years in a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

The results indicate that while LDL cholesterol-lowering therapy is safe in kidney disease patients and can reduce their risk of heart disease and stroke, it does not protect their kidney health as well.

Advertisement

Research has shown that lowering LDL cholesterol with statins can reduce kidney disease patients'' risk of experiencing heart attacks and strokes, but it''s not clear whether it can also reduce the risk of kidney failure, which requires dialysis or kidney transplantation, in these patients.

To investigate, researchers conducted the Study of Heart and Renal Protection (SHARP), which included 6,245 nondialysis chronic kidney disease patients who were randomized to receive a placebo or cholesterol-lowering treatment with simvastatin (a statin) plus ezetimibe (a drug that inhibits the intestinal absorption of cholesterol).
Advertisement

Among the major findings after 5 years of follow-up:
- Simvastatin plus ezetimibe lowered LDL cholesterol by an average of approximately 1 mmol/L (39 mg/dL) compared with placebo.
- Simvastatin plus ezetimibe did not significantly reduce the need for dialysis or transplantation (33.9% cases vs 34.6% cases in the placebo group).
- Treatment had no effect on the speed at which kidney function declined over time.

"The SHARP trial was the largest ever randomized trial in chronic kidney disease and previously showed that simvastatin plus ezetimibe did reduce the risk of heart attack, stroke, vascular stenting, or bypass surgery, but it did not affect the risk of end-stage renal disease," said first author Richard Haynes, MRCP (University of Oxford, UK). "Statins had no effect-neither good nor bad-on kidney function."

Study co-authors include David Lewis, MRCP, Jonathan Emberson, PhD, Christina Reith, FRCP, Lawrence Agodoa, MD, Alan Cass, FRACP, Jonathan Craig, PhD, Dick De Zeeuw, MD, Bo Feldt-Rasmussen, MD, Bengt Fellstrom, MD, Adeera Levin, FRCPC, David Wheeler, FRCP, Robert Walker, FRACP, William Herrington, MD, MRCP, Colin Baigent, FRCP and Martin Landray, PhD, FRCP. The SHARP trial was conducted by an international collaboration of nephrologists and clinical trialists and was coordinated by the University of Oxford, which was the regulatory sponsor of the trial.

Disclosures: The authors reported no financial disclosures. The Study of Heart and Renal Protection (SHARP) was initiated, conducted, and interpreted independently of the principal study funder (Merck/Schering-Plough Pharmaceuticals).

The article, entitled "Effects of Lowering LDL Cholesterol on Progression of Kidney Disease," will appear online at http://jasn.asnjournals.org/ on May 1, 2014.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with more than 14,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.


Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
World AIDS Day 2021 - End Inequalities, End AIDS
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
High Cholesterol Bellīs Palsy Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Diet Lifestyle and Heart Disease Mitral Valve Stenosis And Mitral Valve Replacement Congenital Heart Disease Reiki and Pranic Healing Stress and the Gender Divide 

Recommended Reading
Diabetic Kidney Disease
Diabetic nephropathy refers to kidney damage due very high levels of blood sugar levels in ......
Prenatal Risk Factors Increase Risk of Kidney Disease in Children
A study suggests that certain prenatal risk factors are associated with the development of chronic ....
CDx Test for Diabetic Kidney Disease to be Revealed Soon
The development of a companion diagnostic (CDx) test with the validation of several of its protein ....
Congenital Heart Disease
Heart diseases that are present at birth are called “ Congenital heart diseases”....
High Cholesterol
High cholesterol level in blood are a risk for heart disease and stroke. They get deposited in the w...
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Mitral Valve Stenosis And Mitral Valve Replacement
Mitral valve replacement is a surgical heart procedure to correct either the narrowing (stenosis) or...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use