About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Lack of Sleep Slows Down the Neurons, Says Study

by Anjali Aryamvally on November 9, 2017 at 12:54 PM
Font : A-A+

Lack of Sleep Slows Down the Neurons, Says Study

While it is well established that sleep deprivation slows down reaction time, it is unclear exactly how the lack of sleep affects brain activity and subsequent behavior.

A new Tel Aviv University study published in Nature Medicine finds that individual neurons themselves slow down when we are sleep deprived, leading to delayed behavioral responses to events taking place around us. The neural lapse, or slowdown, affects the brain's visual perception and memory associations.

Advertisement


The study was an international collaboration led by Dr. Yuval Nir of TAU's Sackler Faculty of Medicine and Sagol School of Neuroscience; Prof. Itzhak Fried of UCLA, TAU and Tel Aviv Medical Center; and sleep experts Profs. Chiara Cirelli and Giulio Tononi at the University of Wisconsin-Madison.

"When a cat jumps into the path of our car at night, the very process of seeing the cat slows us down. We're therefore slow to hit the brakes, even when we're wide awake," says Dr. Nir. "When we're sleep-deprived, a local intrusion of sleep-like waves disrupts normal brain activity while we're performing tasks."
Advertisement

Investigators recorded the brain activity of 12 epilepsy patients who had previously shown no or little response to drug interventions at UCLA. The patients were hospitalized for a week and implanted with electrodes to pinpoint the place in the brain where their seizures originated. During their hospitalization, their neuron activity was continuously recorded.

After being kept awake all night to accelerate their medical diagnosis, the patients were presented with images of famous people and places, which they were asked to identify as quickly as possible.

"Performing this task is difficult when we're tired and especially after pulling an all-nighter," says Dr. Nir. "The data gleaned from the experiment afforded us a unique glimpse into the inner workings of the human brain. It revealed that sleepiness slows down the responses of individual neurons, leading to behavioral lapses."

In over 30 image experiments, the research team recorded the electrical activity of nearly 1,500 neurons, 150 of which clearly responded to the images. The scientists examined how the responses of individual neurons in the temporal lobe -- the region associated with visual perception and memory -- changed when sleep-deprived subjects were slow to respond to a task.

"During such behavioral lapses, the neurons gave way to neuronal lapses -- slow, weak and sluggish responses," says Prof. Fried. "These lapses were occurring when the patients were staring at the images before them, and while neurons in other regions of the brain were functioning as usual."

Investigators then examined the dominant brain rhythms in the same circuits by studying the local electrical fields measured during lapses. "We found that neuronal lapses co-occurred with slow brain waves in the same regions," Dr. Nir says. "As the pressure for sleep mounted, specific regions 'caught some sleep' locally. Most of the brain was up and running, but temporal lobe neurons happened to be in slumber, and lapses subsequently followed.

"Since drowsy driving can be as dangerous as drunk driving, we hope to one day translate these results into a practical way of measuring drowsiness in tired individuals before they pose a threat to anyone or anything," Dr. Nir concludes.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
Seasonal Allergy Medications
How to Choose the Best Eczema-Friendly Moisturizer for Children?
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Snoring Sleep Disorder : Restless Legs Syndrome Sleep Disorder: Sleepwalking Periodic Limb Movement Disorder REM Behavior Disorder Sleep Disturbances In Women Sleep Insomnia Obstructive Sleep Apnea Sleep Disorders: A Prelude 

Most Popular on Medindia

Indian Medical Journals Nutam (400mg) (Piracetam) Blood - Sugar Chart Vent Forte (Theophylline) A-Z Drug Brands in India Post-Nasal Drip Find a Hospital Selfie Addiction Calculator Blood Donation - Recipients Sinopril (2mg) (Lacidipine)

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use