Kindlin-3, a protein believed to be limited to the hematopoietic system, has been identified as a major player in both the formation and spread of breast cancer to other organs.
This discovery, published in the May 2014 issue of The FASEB Journal, could open the door to an entirely new class of breast cancer drugs that targets this protein's newly found activity.
"Kill Kindlin-3 to cure cancer," said Elzbieta Pluskota, Ph.D., a researcher involved in the work from the Department of Molecular Cardiology at the Cleveland Clinic Lerner Research Institute in Cleveland, Ohio. "Let our moms, wives, sisters and daughters live long and healthy lives."
"Just when scientists thought they knew all there was to know about Kindlin-3, we now learn that this protein has mostly been flying under the radar in breast cancer research all along," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This discovery puts us on a path toward developing treatments, which slow, stop or reverse the progression of some of the most aggressive breast cancers."