For kidney transplant recipients, infection with a virus called cytomegalovirus (CMV) may lead to devastating complications. New research suggests that extending the period of preventive treatment after kidney transplantation can reduce the risk of CMV disease, according to an upcoming report in the Journal of the American Society of Nephrology (JASN).
Cytomegalovirus is a common virus that is present in many healthy people, rarely causing any problems. However, in kidney transplant patients and others with reduced immune function, CMV infection can cause serious disease. Cytomegalovirus is one of the most common "opportunistic" infections that occur post-transplant. Although CMV infection can happen anytime, most cases occur soon after the end of preventive treatment. Complications related to CMV not only affect the outcome of kidney transplantation but also increase financial costs.
Kidney Transplantation - Causes of Renal failure
Kidney transplantation is the transfer of a healthy kidney from one individual (donor) to another (recipient) through a specialized surgery.
Fu Luan, MD (University of Michigan, Ann Arbor) and colleagues compared three months versus six months of treatment with an antiviral drug (valganciclovir) used to prevent CMV after kidney transplantation. In a retrospective analysis of 222 kidney transplant patients, those receiving six months of valganciclovir preventive treatment had a lower rate of CMV-related disease, about 12 percent, as compared to 24 percent with the three-month treatment period. With adjustment for other factors, six months of preventive therapy reduced the risk of CMV disease by nearly two thirds.
Top 10 Alarming Facts on Kidney Disease
The incidence of lifestyle-related diseases like diabetes and hypertension has resulted in the rise of kidney diseases and treatments around the world.
The researchers hope their study will trigger interest among kidney transplant professionals in evaluating the long-term consequences and cost-effectiveness of the specific treatments they provide. "At the same time, we hope that additional studies will be done to further reduce CMV infection and disease in kidney transplant patients," says Luan.
The study had some important limitations. Because it was a retrospective analysis, the ability to compare the outcomes of these treatments was limited. In addition, the assumptions made in cost-effectiveness study may be limited by the available literature.
Source: Eurekalert
SRM
Quiz on Kidney
The kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine. Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The
 Increasing the Number of Kidney TransplantsIn most transplant centers, the kidneys of very young deceased donors are transplanted together into one patient. | Advertisement
|
Recommended Reading
Latest Research News
