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Kidney Cancer Linked to Mutated Genes- PBRM1, VHL

by Dr. Trupti Shirole on Jan 20 2011 11:24 AM

Kidney Cancer Linked to Mutated Genes- PBRM1, VHL

A mutated gene has been found in 1/3 patients with the most common form of renal cancer. This finding will help researchers understand how kidney cancer develops and in future it might lead to new treatments and earlier diagnosis.

Every individual is born with a gene called PBRM1. However in some people this gene might get damaged leading to the development of cancer. 40% cases of renal cancer presented with a mutated PBRM1 gene. 20 years ago it was known that the main gene involved, the tumor suppressor VHL, is mutated in 8 out of 10 patients. Scientists now believe that these two genes together are implicated in majority of kidney cancers.

Kidney Cancer

Kidney Cancer
According to researchers, that three years on, a group of kidney cancer patients have had no recurrence of their disease, thanks to a new procedure.

Renal cancer is the 7^th most common cancer in men and the 9^th in women. Therefore this new discovery will provide a new insight for future therapeutic measures.

Source-Medindia

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