Key Step Towards New Cancer Therapy That Don't cause Side Effects

by Ramya Rachamanti on  August 6, 2019 at 5:20 PM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

Current cancer treatment produces various side effects. They can be identified by the protein modification which specifically supports proliferation and survival of tumor cells. To address the issue the researchers of Oregon state university take key step toward cancer treatments that leave healthy cells unharmed.
Key Step Towards New Cancer Therapy That Don't cause Side Effects
Key Step Towards New Cancer Therapy That Don't cause Side Effects

Depending on the kind of cancer and the type of treatment, a patient might suffer from many side effects, including anemia, loss of appetite, bleeding, bruising, constipation, delirium, diarrhea, fatigue, hair loss, nausea, sexual issues or bladder problems.

Show Full Article


Scientists at Oregon State University, the University of Central Florida and New York University made the protein-modification discovery while studying neurofibromatosis type 2. The condition, commonly known as NF2, is characterized by the development of tumors of the nervous system called schwannomas.

"The hallmark of tumor cell behavior is their uncontrolled growth," said Maca Franco, professor of biochemistry and biophysics in OSU's College of Science. "Tumors cells need to constantly produce energy and building blocks to replicate."

Researchers led by Franco and Oregon State undergraduate student Jeanine Pestoni found that schwannoma cells produce an oxidant and nitrating agent, peroxynitrite, which modifies an amino acid, tyrosine, in proteins.

When tyrosine becomes nitrated in specific proteins, an effect is the reprogramming of the tumor cells' metabolism, enabling them to proliferate.

"To sustain persistent growth, tumor cells change the way they produce energy and building blocks and present a signature metabolic phenotype that differs from that of normal cells," Franco said. "We discovered that peroxynitrite, the most powerful oxidant produced by cells, controls the metabolic changes that occur in tumor cells of the nervous system and supports their growth. We believe that there are specific proteins that when they become nitrated acquire a new function they did not have before, and this new function may control tumor growth."

Peroxynitrite is produced at high levels in "pathological conditions," she said - such as those found in tumors - but not in normal tissues.

"This opens up the exciting possibility of targeting peroxynitrite production exclusively in tumor cells as a new therapeutic strategy for the treatment of tumors of the nervous system, with minimal to no side effects on normal tissues," Franco added. "We are uncovering a completely new category of targets for the treatment of solid tumors, and not only tumors of the nervous system - it may have broader implications for the treatment of several cancer types. We can go after proteins that usually aren't modified in normal cells; we can target those modified proteins with inhibitors that don't affect normal cells, hopefully developing a treatment with minimal side effects."



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Premium Membership Benefits

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive