Medindia
Advertisement

Key Part of Body’s Immune System Identified

by Colleen Fleiss on February 13, 2019 at 2:17 AM

Key Part of Body’s Immune System Identified
A critical part of the body's immune system with potentially major implications for the treatment of some of the most devastating diseases affecting humans has been discovered by scientists.

Professor Graham Lord, from The University of Manchester, led the study, which could translate into treatments for autoimmune diseases including Cancer, Diabetes, Multiple Sclerosis and Crohn's Disease within a few years.
Advertisement


It is published in the Journal of Clinical Investigation today.

The discovery of the molecular pathway regulated by a tiny molecule - known as microRNA-142 - is a major advance in our understanding of the immune system.
Advertisement

Professor Lord, led the research while at Kings College London in collaboration with Professor Richard Jenner at UCL.

And according to Professor Lord, the discovery could be translated into a viable drug treatment within a few years.

He said: "Autoimmune diseases often target people in the prime of their life creating a significant socio-economic burden on them. Sometimes, the effect can be devastating, causing terrible hardship and suffering.

"But these findings represent a significant step forward in the understanding of the immune system and we believe many people worldwide may benefit."

If the activity of Regulatory T cells is too low, this can cause other immune cells to attack our own body tissues. If these Regulatory T cells are too active, this leads to suppression of immune responses and can allow cancers to evade the immune system.

So being able to control them is a major step forward in our ability to control- and harness - the therapeutic power of the immune system.

Professor Richard Jenner from UCL, who led the computational side of the project, said that: "We were able to trace the molecular fingerprints of this molecule across other genes to determine how it acted as such a critical regulator."

Professor Lord, now Vice President and Dean of the Faculty of Biology, Medicine and Health at The University of Manchester, added: "Scientists over the past decade or so have developed therapies which are able to modulate different pathways of the immune system. We hope that this new discovery will lead to the development of new ways to treat autoimmunity, infectious diseases and cancer and we are incredibly excited about where this may lead."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Immunisation Myasthenia Gravis Cytokines - Part of Body's Defence System 

Recommended Reading
Ways to Boost Your Immune System during Cold and Flu Season
Your immune system has to be strong to fight the bacteria and viruses that enter the body and cause ...
Fungus Aspergillus Fumigates Cripples Immune System
Research team from the University of Jena clarifies the mechanism of gliotoxin, a mycotoxin from ......
Chaos in the Body Optimizes Immune System
An entirely new mechanism in the way that bodily cells regulate themselves - through chaos has been ...
New Mechanism to Activate the Immune System Against Cancer Revealed
A novel mechanism for activating the immune system against cancer cells has been developed by ......
Cytokines - Part of Body's Defence System
Cytokines are chemical signaling molecules produced by immune cells of our body and help cells in th...
Myasthenia Gravis
Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gra...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use