About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Key Areas of Measles Virus Polymerase to Target for Antiviral Drug Development Discovered

by Colleen Fleiss on August 24, 2019 at 5:25 PM
Font : A-A+

Key Areas of Measles Virus Polymerase to Target for Antiviral Drug Development Discovered

Targeting specific areas of the measles virus polymerase was found to fight the measles virus and be used as an approach to developing new antiviral drugs to treat the serious infectious disease, according to a study by the Institute for Biomedical Sciences at Georgia State University published in PLoS Pathogens.

Measles is a highly contagious virus that can lead to serious health complications and death. It begins with a fever, cough, runny nose and red eyes followed by a rash of tiny, red spots that starts at the head and spreads to the rest of the body. Although declared eliminated in the United States in 2000, the Centers for Disease Control and Prevention says the U.S. is experiencing the greatest number of measles cases reported since the early 1990s.

Advertisement


While an effective vaccine exists, there has been a steady decline in the number of people being vaccinated against the measles virus. Most new cases were among unvaccinated individuals, making the development of an effective treatment strategy complementing vaccination a public health priority. There are no antivirals licensed to treat measles.

"We have advanced current understanding of the underlying mechanism of viral RNA-dependent RNA polymerase advancement along the encapsidated genome - a poorly understood and not well characterized mechanism - by identifying and characterizing the dynamic interactions between its constituents," said Venice Du Pont, first author of the study and a Ph.D. candidate working in Dr. Richard Plemper's lab in the Institute for Biomedical Sciences.
Advertisement

This insight has revealed a vulnerability that could be exploited as a target for small-molecule antiviral drugs.

"In recent years, enormous progress has been made to successfully target protein-protein interfaces for therapeutic purpose with chemical fragment libraries," said Dr. Richard K. Plemper, professor in the Institute for Biomedical Sciences and senior author on the study. "The newly identified interface in the paramyxovirus polymerase machinery meets key criteria of a druggable target, and is very likely mechanistically conserved in highly pathogenic paramyxoviruses closely related to measles virus such as the zoonotic Nipah virus, against which we have currently no treatment option."

The study was funded by the National Institutes of Health's National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Cancer Institute and National Eye Institute.

An additional co-author is Dr. Yi Jiang, associate professor in the College of Arts & Sciences' Department of Mathematics and Statistics at Georgia State.

"This work would not have been possible without this effective collaboration across diverse departments," said Plemper, emphasizing how a collegial atmosphere at Georgia State fosters groundbreaking discoveries.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chicken Pox Drug Toxicity Measles Shigellosis Signature Drug Toxicity Drugs Banned in India Rashes Symptom Evaluation Postherpetic Neuralgia Neck Cracking 

Recommended Reading
Measles
Measles is a viral infection with symptoms of fever,and rashes. Measles is prevented by vaccination ...
Test Your Knowledge on Measles
Measles, also known as morbilli or rubeola or red measles, is a highly contagious, rash-causing ......
Targeting Measles Virus Polymerase Aids to Develop New Drugs
Researchers identify specific areas of measles virus polymerase, a protein complex that copies the ....
Measles Elimination Requires Political Support, Strong Public Health Systems
Strong public health systems and political support are required to ensure everyone is immunized and ...
Chicken Pox
Chicken pox is an acute and highly contagious viral infection caused by the varicella zoster virus....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
Neck Cracking
Neck cracking or neck popping is caused by quick movements to loosen the ligaments and joints of the...
Postherpetic Neuralgia
Postherpetic neuralgia is a type of nerve pain that occurs following shingles or herpes zoster....
Rashes Symptom Evaluation
The lesions in rashes vary from small skin discolorations to large fluid-filled bullae....
Shigellosis
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use