An understanding of metabolism is pivotal to comprehending the phenotypic behavior of all living organisms (including humans) where metabolism is integral to health and proper functioning.
Metabolites are the intermediate products of metabolic reactions catalyzed by various enzymes that naturally occur within cells. Researchers in Japan have created a database of metabolites from blood samples collected from over 5,000 Japanese volunteers, making it freely available online as a valuable resource for researchers around the world.
Research Finds MRI Spectroscopy is Highly Sensitive for Lipid-Soluble Metabolites from UC-MSCs
Researchers have made use of methanol-chloroform and perchloric acid in order to extract lipid-soluble metabolites and water-soluble metabolites from human mesenchymal stem cells.
Advertisement
‘A database of metabolites, jMorp, contains information about 306 metabolites and 256 common proteins found in humans.’
Tweet it Now
Metabolites and proteins control many of the processes inside our bodies, and also inform the interaction between our cells and their surroundings. Understanding these compounds and how they relate to each other more, could help researchers to evaluate the health state of people and develop new personalised treatments for various diseases.
The database, which bioinformatics scientist Shu Tadaka from Tohoku University and his colleagues called jMorp, contains information about 306 metabolites and 256 common proteins found in humans. This includes their frequency, concentration, and how often they appeared in males or females and at what age. The database is unique in that, instead of just displaying raw data, it offers visitors a chance to see how the different metabolites correlate to each other graphically, paving the way for further studies to identify how these metabolites and proteins relate to each other.
![Glucose Metabolites Prevent Platelets From Arthritis, Sepsis]( "Glucose Metabolites Prevent Platelets From Arthritis, Sepsis")
GLUT3 plays the predominant role in platelet activation and mice with reduced GLUT3 in platelets survived pulmonary embolism.
"The information in jMorp is obtained from statistical data created by aggregating individual data," says Tadaka. "An independent committee has carefully considered all ethical issues before allowing us access to this data."
Similar databases cover other countries or regions, such as the United Kingdom and the Republic of Ireland, but some have limitations due to inconsistent data collection or small sample size. The large number of healthy individuals who contributed samples to jMorp makes it particularly useful. The researchers also collected and analysed data using the same method and at the same institute, which minimizes measurement errors. In addition, they took extra measures to exclude any low-quality samples and to ensure quality control throughout the processes of collecting, storing and analysing the plasma samples. These make jMorp especially reliable as a resource for scientists, especially biochemists and medical researchers.
To make it relevant and useful to other researchers, the Japanese team have setup jMorp in a user-friendly format that allows visitors to reach the data they need easily, as well as pull up comparisons and relationships between different compounds displayed visually. Users can search for the type of compound they are looking for either by name or specifications. The summary of the data can be downloaded and correlation graphs can be saved as image files.
The database is an ongoing effort and the researchers produce updated annual versions as they collect and analyse more samples. They also plan to offer more insight about the metabolites and proteins they document by applying new methods of analysis.
Source: Eurekalert
Glucose Metabolites Prevent Platelets From Arthritis, Sepsis
GLUT3 plays the predominant role in platelet activation and mice with reduced GLUT3 in platelets survived pulmonary embolism.
Advertisement
"The information in jMorp is obtained from statistical data created by aggregating individual data," says Tadaka. "An independent committee has carefully considered all ethical issues before allowing us access to this data."
Similar databases cover other countries or regions, such as the United Kingdom and the Republic of Ireland, but some have limitations due to inconsistent data collection or small sample size. The large number of healthy individuals who contributed samples to jMorp makes it particularly useful. The researchers also collected and analysed data using the same method and at the same institute, which minimizes measurement errors. In addition, they took extra measures to exclude any low-quality samples and to ensure quality control throughout the processes of collecting, storing and analysing the plasma samples. These make jMorp especially reliable as a resource for scientists, especially biochemists and medical researchers.
To make it relevant and useful to other researchers, the Japanese team have setup jMorp in a user-friendly format that allows visitors to reach the data they need easily, as well as pull up comparisons and relationships between different compounds displayed visually. Users can search for the type of compound they are looking for either by name or specifications. The summary of the data can be downloaded and correlation graphs can be saved as image files.
The database is an ongoing effort and the researchers produce updated annual versions as they collect and analyse more samples. They also plan to offer more insight about the metabolites and proteins they document by applying new methods of analysis.
Source: Eurekalert
Risk of Breast Cancer Reduced With Favorable Ratio of Estrogen Metabolites
More favorable ratio of estrogen metabolites is exhibited in postmenopausal women with diverse gut bacteria, which is in turn associated with reduced risk for breast cancer.
Advertisement
 Metabolites Production Operated by Circadian RhythmsCircadian rhythms, i.e. our own body clock, significantly control the production of key building blocks like amino acids, carbohydrates and lipids, researchers have discovered. | Advertisement
|
Advertisement
Recommended Readings
Latest Research News
Electrical stimulation improves Alzheimer's patients' cognitive function and correlates with restored cortical plasticity.
South Korea's total fertility rate, averaging the number of children a woman aged 15-49 has in her lifetime, dropped to 0.81.
Scientists identified mechanisms governing immune cells, selectively removing troublemakers to reshape skin immunity. Benefits those with psoriasis, vitiligo.
By 2050, an anticipated increase from 494 million cases in 2020 to 1.06 billion people with musculoskeletal disabilities is expected.
Experts consulted by GlobalData anticipate a significant overhaul in the Gaucher disease scenario because of forthcoming gene therapies in development.