About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Isolating Therapy-Resistant Leukemia Cells to Prevent Relapse

by Dr. Trupti Shirole on December 17, 2016 at 10:22 AM
Font : A-A+

 Isolating Therapy-Resistant Leukemia Cells to Prevent Relapse

Chemotherapy often fails in leukemia when resistant cells survive treatment and bring about a relapse of the disease (recurrence). New therapies are therefore needed to eliminate these cells.

A small population of inactive leukemia cells that is responsible for relapse of the disease has been identified by Dr. Irmela Jeremias from Helmholtz Zentrum München and her colleagues. Now the way is paved for research into new therapies that prevent disease relapse by eliminating the remaining, so-called dormant leukemia cells.

Advertisement


The research results have now been published in the Cancer Cell journal.

The team of scientists headed by Jeremias, head of the 'Apoptosis' research group in the Gene Vectors Research Unit (AGV) at the Helmholtz Zentrum München, has now isolated and characterized therapy-resistant cells for the first time. "Previously the biological principles responsible for a relapse in leukemia were not fully understood," says Jeremias. "Our new approach is to isolate dormant cells, which gives us the first possibility of developing therapies that switch off these cells."
Advertisement

Isolated cells respond to drugs

"We have found a method to dissociate dormant leukemia cells from their surroundings, where they are safe from attacks by therapeutics," explains Sarah Ebinger, doctoral candidate in the AGV and the article's first author. With the help of modern genetic engineering and dyes that mark cell growth, the scientists isolated cells and identified a rare cell type that resembled cells triggering relapse. These cells were inactive and resistant to therapy.

"We then found out that these cells, once they have been dissolved out of their surroundings, are indeed susceptible to therapy and react well to therapeutics," adds Erbey Özdemir, doctoral candidate in the AGV. "This has brought us a small step closer to the global goal of preventing disease relapse in patients suffering leukemia," says Jeremias. "It might serve as basis for new therapies that destroy resistant leukemia cells before they induce relapse."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Leukemia Parkinsons Disease Surgical Treatment Chronic Myeloid Leukemia Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Multiple Myeloma Bone Marrow Transplantation Hairy Cell Leukemia 

Most Popular on Medindia

Post-Nasal Drip Iron Intake Calculator Find a Hospital Turmeric Powder - Health Benefits, Uses & Side Effects Blood Pressure Calculator The Essence of Yoga Calculate Ideal Weight for Infants A-Z Drug Brands in India Loram (2 mg) (Lorazepam) Nutam (400mg) (Piracetam)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE

×

Isolating Therapy-Resistant Leukemia Cells to Prevent Relapse Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests