Rats with severe spinal cord injury are learning to walk—and run—again in a lab. Grégoire Courtine, of the École Polytechnique Fédérale de Lausanne (EPFL), reported that rats in his lab are not only voluntarily initiating a walking gait, but they were sprinting, climbing up stairs, and avoiding obstacles after a couple of weeks of neurorehabilitation with a combination of a robotic harness and electrical chemical stimulation. The report was made last June in the journalScience.
Now, at the 2013 Annual Meeting of the American Association for the Advancement of Science (AAAS) in Boston, Courtine describes this research in detail and the next steps towards clinical trials to be done in Switzerland. Courtine holds the International Paraplegic Foundation (IRP) Chair in Spinal Cord Repair at EPFL. At AAAS, in a symposium titled, "Engineering the Nervous System: Solutions to Restore Sight, Hearing, and Mobility," he outlines the range of neuroprosthetic technologies developed in his lab, which aim to restore voluntary control of locomotion after severe spinal cord injury. He explains how he and his colleagues are interfacing the central nervous system with stretchable spinal electrode arrays controlled with smart stimulation algorithms - combined with novel robotic rehabilitation - and shows videos of completely paralyzed rats voluntarily moving after only weeks of treatment. Courtine expects to begin clinical trials in human patients within the next two years. At AAAS, he presents the 9 million euro European project NeuWalk, an effort dedicated to the transfer of technology from rats over to humans with spinal cord damage through development of effective neuroprosthetic systems for rehabilitation.