Is Cannabidiol is Safe and Effective for Pain Management?

Following arthroscopic rotator cuff repair, Cannabidiol (CBD) was found to be effective in improving immediate post-operative pain, revealed research.

Michael J. Alaia, MD, NYU Langone Health in New York City, sought to determine if CBD could be safe and effective as a pain medicine for patients after rotator cuff surgery. Dr. Alaia and colleagues established a multi-center, placebo-controlled, randomized, double-blinded trial conducted on patients undergoing rotator cuff repair. Dr. Alaia enrolled 80 patients from 18 to 75 years of age and one group received 25mg of CBD (Oravexx, Orcosa Pharmaceuticals, USA) TID if patients weighed less than 176 pounds (80kg) and 50mg of CBD if they weighed more than 176 pounds (80kg) for 14 days, and the control group was given a placebo.

Rotator Cuff Injury - Causes - Symptoms - Diagnosis - Treatment - Prevention
Rotator cuff injury can be a tendinitis, a strain, or a tear of the rotator cuff muscles. The rotator cuff is made up of four tendons that fuse to surround the shoulder joint.

‘CBD is safe and effective in reducing pain in the immediate peri-operative period following rotator cuff repair and should be considered in postoperative multimodal pain control.’

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Currently, Cannabidiol is FDA approved for the treatment of some seizures and other studies have suggested the therapy may help treat anxiety, cognition, and movement disorders though research has yet to prove it can be used to treat these disorders.

Patients were followed-up on days one, two, seven, and 14, and the Visual Analog Scale (VAS) for pain, opioid consumption, and satisfaction with pain control were recorded. The VAS is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between “no pain” and “worst pain.” Additionally, liver function tests (LFT) were done on days seven and 14 to assess safety, and nausea was monitored.

On day one, the VAS pain score was significantly lower in those receiving CBD (4.1 +- 3.0 vs 6.0 +- 3.1, p = 0.01), which also meets VAS MCID for shoulder arthroscopy (1.2-1.4). Patient satisfaction with pain control trended towards significance favoring the CBD group (72% vs 60%, p = 0.072). However, there were no statistically significant differences in opioid consumption (16.4mme +- 12.7 vs 20.6mme +- 14.4, p = 0.186), which was relatively small in both groups.

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Notably, patients receiving 50 mg of CBD reported lower VAS scores at day 1 (3.9 +- 3.3 vs 4.6 +-2.5 +- 6.0 +- 3.1, p = 0.0394) and higher satisfaction with pain control at day 1 and 2 (8.1 +- 2.3, 5.8 +- 3.3, 5.9 vs 3.6, p = 0.0175 | 7.8 +- 1.8 vs 6.3 +- 3.0 6.0 +- 3.2, p = 0.05) compared to those receiving 25 mg of CBD and control group respectively. On day sever and day 14, there were no statistically significant differences in VAS score, opioid consumption, or patient satisfaction with pain control (p>0.05 for all). There were no significant differences in nausea or LFTs post-operatively (p > 0.05).

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Knee pain is often a consequence of the erect posture of humans, due to which the knee joints have to take the weight of the body. It causes symptoms of discomfort and disability in people of all age groups. Knee joint replacement has revolutionized the treatment of several knee joint diseases that cause pain. Test your knowledge on knee pain by taking this quiz.

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