Is Bipolar Disorder Linked to Parkinson’s Disease?

People with bipolar disorder were nearly seven times as likely to develop Parkinson's disease as people who did not have bipolar disorder, stated new study.

People who have bipolar disorder may be at an increased risk to later develop Parkinson’s disease than people who do not have bipolar disorder, revealed new study published in the online issue of Neurology®, the medical journal of the American //Academy of Neurology.

"Previous studies have shown a relationship between depression and Parkinson's disease, but few studies have looked at whether there is a relationship between bipolar disorder and Parkinson's," said study author Mu-Hong Chen, MD, PhD, of Taipei Veterans General Hospital in Taiwan.

Bipolar Disorder-Causes-Risk Factors-Types-Symptoms-Treatment-Complications-FAQs
Bipolar Disorder is a brain disorder in which people show “mood swings”. Changes in the level of neurotransmitters in brain, and psychosocial factors are thought to be involved.

For the study, researchers examined a national Taiwanese health database for people were diagnosed with bipolar disorder between 2001 and 2009 and who had no history of Parkinson's disease, for a total of 56,340 people. They were matched with 225,360 people of the same age, sex and other factors who had never been diagnosed with bipolar disorder or Parkinson's disease as a control group. Then the two groups were followed until the end of 2011.

During the study, 372 of the people with bipolar disorder developed Parkinson's disease, or 0.7 percent, compared to 222 of those who did not have bipolar disorder, or 0.1 percent.

After adjusting for other factors that could affect the risk of developing Parkinson's disease, such as age, sex, use of antipsychotic medications, and medical issues such as traumatic brain injury and cerebrovascular diseases, people with bipolar disorder were nearly seven times as likely to develop Parkinson's disease as people who did not have bipolar disorder.

Quiz on Parkinson’s Disease
Parkinson's disease (PD) is a chronic and progressive nervous system disorder that results in a gradual loss of muscle control. It has an impact on the body's ability to control movement.

The people with bipolar disorder who developed Parkinson's disease did so at a younger age than the control group members who developed the disease--64 years old at diagnosis compared to 73 years old.

A total of 94 percent of those with bipolar disorder were hospitalized less than once per year; 3 percent were hospitalized one to two times per year; and 3 percent were hospitalized more than two times per year. Those who were hospitalized more than two times per year were six times more likely to develop Parkinson's disease than those who were hospitalized less than once per year. People who were hospitalized one to two times per year were four times more likely to develop Parkinson's disease than those who were hospitalized less than once per year.

Strength for Today, Hope for Tomorrow - World Bipolar Day
World bipolar day (WBD) is observed on 30th March every year to raise awareness and to eliminate the social stigma associated with this condition.

"Further studies are needed to investigate whether these diseases share underlying processes or changes in the brain," Chen said. "These could include genetic alterations, inflammatory processes or problems with the transmission of messages between brain cells. If we could identify the underlying cause of this relationship, that could potentially help us develop treatments that could benefit both conditions."

A limitation of the study is it included only people who sought medical help for their bipolar disorder. Also, the database did not include information on family history of Parkinson's disease or environmental factors that could increase people's risk of developing the disease.

Source-Eurekalert